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Identification
HMDB Protein ID HMDBP12656
Secondary Accession Numbers None
Name Endothelin-converting enzyme 1
Synonyms
  1. ECE-1
Gene Name ECE1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Converts big endothelin-1 to endothelin-1.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of vasoconstriction
G-protein coupled receptor signaling pathway
heart development
regulation of systemic arterial blood pressure by endothelin
ear development
peptide hormone processing
protein processing
bradykinin catabolic process
calcitonin catabolic process
endothelin maturation
hormone catabolic process
substance P catabolic process
embryonic digit morphogenesis
positive regulation of receptor recycling
Cellular Component
extracellular vesicular exosome
plasma membrane
perinuclear region of cytoplasm
early endosome
vesicle
external side of plasma membrane
membrane
lysosomal membrane
intrinsic component of endosome membrane
Weibel-Palade body
integral to membrane
endosome
Molecular Function
endopeptidase activity
metalloendopeptidase activity
zinc ion binding
protein homodimerization activity
peptide hormone binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 758
Molecular Weight 87162.975
Theoretical pI 6.498
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 69-89;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P42892
UniProtKB/Swiss-Prot Entry Name ECE1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol. 2009 Apr;27(4):378-86. doi: 10.1038/nbt.1532. Epub 2009 Apr 6. [PubMed:19349973 ]
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  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  7. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  8. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  9. Lewandrowski U, Moebius J, Walter U, Sickmann A: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. Mol Cell Proteomics. 2006 Feb;5(2):226-33. Epub 2005 Oct 31. [PubMed:16263699 ]
  10. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [PubMed:21269460 ]
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  12. Schmidt M, Kroger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H: Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). FEBS Lett. 1994 Dec 19;356(2-3):238-43. doi: 10.1016/0014-5793(94)01277-6. [PubMed:7805846 ]
  13. Yorimitsu K, Moroi K, Inagaki N, Saito T, Masuda Y, Masaki T, Seino S, Kimura S: Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. Biochem Biophys Res Commun. 1995 Mar 17;208(2):721-7. doi: 10.1006/bbrc.1995.1397. [PubMed:7695628 ]
  14. Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K: Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem Biophys Res Commun. 1995 Feb 15;207(2):807-12. doi: 10.1006/bbrc.1995.1258. [PubMed:7864876 ]
  15. Valdenaire O, Rohrbacher E, Mattei MG: Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). J Biol Chem. 1995 Dec 15;270(50):29794-8. doi: 10.1074/jbc.270.50.29794. [PubMed:8530372 ]
  16. Valdenaire O, Lepailleur-Enouf D, Egidy G, Thouard A, Barret A, Vranckx R, Tougard C, Michel JB: A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization. Eur J Biochem. 1999 Sep;264(2):341-9. doi: 10.1046/j.1432-1327.1999.00602.x. [PubMed:10491078 ]
  17. Schweizer A, Valdenaire O, Nelbock P, Deuschle U, Dumas Milne Edwards JB, Stumpf JG, Loffler BM: Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations. Biochem J. 1997 Dec 15;328 ( Pt 3):871-7. doi: 10.1042/bj3280871. [PubMed:9396733 ]
  18. Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin. Sci Rep. 2016 Mar 2;6:22413. doi: 10.1038/srep22413. [PubMed:26931059 ]
  19. Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S: Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin. Sci Rep. 2016 Apr 22;6:24333. doi: 10.1038/srep24333. [PubMed:27102936 ]
  20. Schulz H, Dale GE, Karimi-Nejad Y, Oefner C: Structure of human endothelin-converting enzyme I complexed with phosphoramidon. J Mol Biol. 2009 Jan 9;385(1):178-87. doi: 10.1016/j.jmb.2008.10.052. Epub 2008 Nov 1. [PubMed:18992253 ]
  21. Hofstra RM, Valdenaire O, Arch E, Osinga J, Kroes H, Loffler BM, Hamosh A, Meijers C, Buys CH: A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Am J Hum Genet. 1999 Jan;64(1):304-8. doi: 10.1086/302184. [PubMed:9915973 ]