Hmdb loader
Identification
HMDB Protein ID HMDBP12657
Secondary Accession Numbers None
Name Endothelin-converting enzyme 2
Synonyms
  1. ECE-2
Gene Name ECE2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cell-cell signaling
G-protein coupled receptor signaling pathway
peptide hormone processing
protein processing
methylation
Cellular Component
plasma membrane
cytoplasmic vesicle membrane
transport vesicle membrane
integral to membrane
Golgi membrane
Molecular Function
metal ion binding
metalloendopeptidase activity
methyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 811
Molecular Weight 91210.3
Theoretical pI 5.314
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 107-127;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P0DPD6
UniProtKB/Swiss-Prot Entry Name ECE2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
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  4. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9. [PubMed:9628581 ]
  5. Lorenzo MN, Khan RY, Wang Y, Tai SC, Chan GC, Cheung AH, Marsden PA: Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. Biochim Biophys Acta. 2001 Nov 11;1522(1):46-52. doi: 10.1016/s0167-4781(01)00283-4. [PubMed:11718899 ]
  6. Mzhavia N, Pan H, Che FY, Fricker LD, Devi LA: Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides. J Biol Chem. 2003 Apr 25;278(17):14704-11. doi: 10.1074/jbc.M211242200. Epub 2003 Jan 30. [PubMed:12560336 ]