Hmdb loader
Identification
HMDB Protein ID HMDBP12659
Secondary Accession Numbers None
Name Organic solute transporter subunit alpha
Synonyms
  1. OST-alpha
  2. Solute carrier family 51 subunit alpha
Gene Name SLC51A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
Pathways
  • Bile secretion
Reactions Not Available
GO Classification
Biological Process
bile acid and bile salt transport
bile acid secretion
organic substance transport
Cellular Component
endoplasmic reticulum membrane
protein-containing complex
plasma membrane
basolateral plasma membrane
integral to membrane
Molecular Function
transmembrane transporter activity
protein homodimerization activity
bile acid transmembrane transporter activity
protein heterodimerization activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 340
Molecular Weight 37758.635
Theoretical pI 8.4
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 49-69;88-108;115-135;182-202;220-240;256-276;298-317;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8R000
UniProtKB/Swiss-Prot Entry Name OSTA_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  4. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N: The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem. 2005 Feb 25;280(8):6960-8. doi: 10.1074/jbc.M412752200. Epub 2004 Nov 24. [PubMed:15563450 ]
  5. Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N: OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9. doi: 10.1002/hep.20961. [PubMed:16317684 ]
  6. Frankenberg T, Rao A, Chen F, Haywood J, Shneider BL, Dawson PA: Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G912-22. doi: 10.1152/ajpgi.00479.2005. Epub 2005 Dec 15. [PubMed:16357058 ]
  7. Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL: Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May;43(5):1013-21. doi: 10.1002/hep.21158. [PubMed:16628672 ]
  8. Li N, Cui Z, Fang F, Lee JY, Ballatori N: Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem J. 2007 Nov 1;407(3):363-72. doi: 10.1042/BJ20070716. [PubMed:17650074 ]
  9. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA: The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3891-6. doi: 10.1073/pnas.0712328105. Epub 2008 Feb 21. [PubMed:18292224 ]
  10. Christian WV, Li N, Hinkle PM, Ballatori N: beta-Subunit of the Ostalpha-Ostbeta organic solute transporter is required not only for heterodimerization and trafficking but also for function. J Biol Chem. 2012 Jun 15;287(25):21233-43. doi: 10.1074/jbc.M112.352245. Epub 2012 Apr 25. [PubMed:22535958 ]