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Identification
HMDB Protein ID HMDBP12675
Secondary Accession Numbers None
Name ATP-binding cassette sub-family D member 3
Synonyms
  1. 70 kDa peroxisomal membrane protein
  2. PMP70
Gene Name ABCD3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239).
Pathways
  • ABC transporters
  • Peroxisome
Reactions Not Available
GO Classification
Biological Process
long-chain fatty acid import into peroxisome
protein import into peroxisome membrane
response to drug
lipid transport
peroxisome organization
fatty acid biosynthetic process
response to organic cyclic compound
fatty acid beta-oxidation
very long-chain fatty acid catabolic process
Cellular Component
cytosol
mitochondrion
peroxisomal matrix
peroxisomal membrane
peroxisome
membrane
intracellular membrane-bounded organelle
integral to membrane
Molecular Function
long-chain fatty acid transporter activity
protein self-association
ATP binding
protein homodimerization activity
ATPase activity
ATPase-coupled transmembrane transporter activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 659
Molecular Weight 75475.3
Theoretical pI 9.363
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 84-104;126-146;224-244;313-333;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P28288
UniProtKB/Swiss-Prot Entry Name ABCD3_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  9. Kamijo K, Kamijo T, Ueno I, Osumi T, Hashimoto T: Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: a member of ATP-binding cassette transporters. Biochim Biophys Acta. 1992 Feb 11;1129(3):323-7. doi: 10.1016/0167-4781(92)90510-7. [PubMed:1536884 ]
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