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Showing Protein Apolipoprotein D (HMDBP12684)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12684
Secondary Accession Numbers None
Name Apolipoprotein D
Synonyms
  1. Apo-D
  2. ApoD
Gene Name APOD
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of cytokine production involved in inflammatory response
intracellular receptor signaling pathway
negative regulation of lipoprotein lipid oxidation
negative regulation of protein import into nucleus
negative regulation of smooth muscle cell-matrix adhesion
negative regulation of T cell migration
negative regulation of focal adhesion assembly
negative regulation of monocyte chemotactic protein-1 production
response to reactive oxygen species
response to drug
angiogenesis
glucose metabolic process
tissue regeneration
negative regulation of platelet-derived growth factor receptor signaling pathway
brain development
negative regulation of smooth muscle cell proliferation
peripheral nervous system axon regeneration
aging
lipid metabolic process
response to axon injury
Cellular Component
cytoplasm
endoplasmic reticulum
extracellular vesicular exosome
dendrite
perinuclear region of cytoplasm
cytosolic ribosome
extracellular region
neuronal cell body
extracellular space
Molecular Function
cholesterol binding
lipid transporter activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 189
Molecular Weight 21275.37
Theoretical pI 5.14
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P05090
UniProtKB/Swiss-Prot Entry Name APOD_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Schindler PA, Settineri CA, Collet X, Fielding CJ, Burlingame AL: Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion. Protein Sci. 1995 Apr;4(4):791-803. [PubMed:7613477 ]
  5. Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [PubMed:16335952 ]
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  8. Nilsson J, Ruetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G: Enrichment of glycopeptides for glycan structure and attachment site identification. Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18. [PubMed:19838169 ]
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  10. Jia W, Lu Z, Fu Y, Wang HP, Wang LH, Chi H, Yuan ZF, Zheng ZB, Song LN, Han HH, Liang YM, Wang JL, Cai Y, Zhang YK, Deng YL, Ying WT, He SM, Qian XH: A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol Cell Proteomics. 2009 May;8(5):913-23. doi: 10.1074/mcp.M800504-MCP200. Epub 2009 Jan 12. [PubMed:19139490 ]
  11. Drayna D, Fielding C, McLean J, Baer B, Castro G, Chen E, Comstock L, Henzel W, Kohr W, Rhee L, et al.: Cloning and expression of human apolipoprotein D cDNA. J Biol Chem. 1986 Dec 15;261(35):16535-9. [PubMed:3453108 ]
  12. Drayna DT, McLean JW, Wion KL, Trent JM, Drabkin HA, Lawn RM: Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily. DNA. 1987 Jun;6(3):199-204. doi: 10.1089/dna.1987.6.199. [PubMed:2439269 ]
  13. Yang CY, Gu ZW, Blanco-Vaca F, Gaskell SJ, Yang M, Massey JB, Gotto AM Jr, Pownall HJ: Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. Biochemistry. 1994 Oct 18;33(41):12451-5. doi: 10.1021/bi00207a011. [PubMed:7918467 ]
  14. Holzfeind P, Merschak P, Dieplinger H, Redl B: The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily. Exp Eye Res. 1995 Oct;61(4):495-500. doi: 10.1016/s0014-4835(05)80145-9. [PubMed:8549691 ]
  15. Balbin M, Freije JM, Fueyo A, Sanchez LM, Lopez-Otin C: Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease. Biochem J. 1990 Nov 1;271(3):803-7. doi: 10.1042/bj2710803. [PubMed:2244881 ]
  16. Halim A, Nilsson J, Ruetschi U, Hesse C, Larson G: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. Mol Cell Proteomics. 2012 Apr;11(4):M111.013649. doi: 10.1074/mcp.M111.013649. Epub 2011 Dec 14. [PubMed:22171320 ]
  17. Peitsch MC, Boguski MS: Is apolipoprotein D a mammalian bilin-binding protein? New Biol. 1990 Feb;2(2):197-206. [PubMed:2083249 ]