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Showing Protein Alkaline protease 1 (HMDBP12687)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12687
Secondary Accession Numbers None
Name Alkaline protease 1
Synonyms
  1. ALP
  2. Aspergillopeptidase B
  3. Aspergillus proteinase B
  4. Elastase
  5. Elastinolytic serine proteinase
  6. Oryzin
Gene Name ALP1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Secreted alkaline protease that allows assimilation of proteinaceous substrates. Acts as a significant virulence factor in invasive aspergillosis. Involved in immune evasion from the human and mice complement systems during infection. Efficiently cleaves important components of the complement cascade such as such as C3, C4, C5, and C1q, as well as IgG, which leads to down-regulation of complement activation at the hyphal surface.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
complement activation
elastin catabolic process
evasion of host immune response via regulation of host complement system
protein catabolic process
pathogenesis
Cellular Component
extracellular region
extracellular space
Molecular Function
peptidase activity
fibrinogen binding
IgE binding
serine-type peptidase activity
serine-type endopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 403
Molecular Weight 42189.75
Theoretical pI 6.813
Pfam Domain Function
Signals
  • 1-21;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P28296
UniProtKB/Swiss-Prot Entry Name ORYZ_ASPFU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 2005 Dec 22;438(7071):1151-6. doi: 10.1038/nature04332. [PubMed:16372009 ]
  2. Jaton-Ogay K, Suter M, Crameri R, Falchetto R, Fatih A, Monod M: Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus. FEMS Microbiol Lett. 1992 Apr 15;71(2):163-8. doi: 10.1016/0378-1097(92)90506-j. [PubMed:1601287 ]
  3. Kolattukudy PE, Lee JD, Rogers LM, Zimmerman P, Ceselski S, Fox B, Stein B, Copelan EA: Evidence for possible involvement of an elastolytic serine protease in aspergillosis. Infect Immun. 1993 Jun;61(6):2357-68. doi: 10.1128/iai.61.6.2357-2368.1993. [PubMed:8500876 ]
  4. Chow LP, Liu SL, Yu CJ, Liao HK, Tsai JJ, Tang TK: Identification and expression of an allergen Asp f 13 from Aspergillus fumigatus and epitope mapping using human IgE antibodies and rabbit polyclonal antibodies. Biochem J. 2000 Mar 1;346 Pt 2:423-31. [PubMed:10677362 ]
  5. Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann S: A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence. Infect Immun. 2009 Sep;77(9):4041-50. doi: 10.1128/IAI.00425-09. Epub 2009 Jun 29. [PubMed:19564390 ]
  6. Sharon H, Hagag S, Osherov N: Transcription factor PrtT controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus. Infect Immun. 2009 Sep;77(9):4051-60. doi: 10.1128/IAI.00426-09. Epub 2009 Jun 29. [PubMed:19564385 ]
  7. Behnsen J, Lessing F, Schindler S, Wartenberg D, Jacobsen ID, Thoen M, Zipfel PF, Brakhage AA: Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5. Infect Immun. 2010 Aug;78(8):3585-94. doi: 10.1128/IAI.01353-09. Epub 2010 May 24. [PubMed:20498262 ]