Hmdb loader
Identification
HMDB Protein ID HMDBP12701
Secondary Accession Numbers None
Name DNA-directed RNA polymerase III subunit RPC9
Synonyms
  1. RNA polymerase III subunit C9
  2. Calcitonin gene-related peptide-receptor component protein
  3. CGRP-RCP
  4. CGRP-receptor component protein
  5. CGRPRCP
  6. HsC17
Gene Name CRCP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
Pathways
  • RNA polymerase
Reactions Not Available
GO Classification
Biological Process
neuropeptide signaling pathway
transcription by RNA polymerase III
defense response to virus
innate immune response
transcription initiation from RNA polymerase III promoter
positive regulation of type I interferon production
Cellular Component
cytosol
DNA-directed RNA polymerase III complex
plasma membrane
nucleoplasm
DNA polymerase III complex
acrosomal vesicle
Molecular Function
calcitonin gene-related peptide receptor activity
DNA-directed RNA polymerase activity
nucleotide binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 115
Molecular Weight 16870.885
Theoretical pI 5.013
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O75575
UniProtKB/Swiss-Prot Entry Name RPC9_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  8. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C: An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. Mol Cell Biol. 2003 Jan;23(1):195-205. doi: 10.1128/MCB.23.1.195-205.2003. [PubMed:12482973 ]