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Showing Protein Calcitonin receptor (HMDBP12709)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12709
Secondary Accession Numbers None
Name Calcitonin receptor
Synonyms
  1. CT-R
Gene Name CALCR
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993).
Pathways
  • Neuroactive ligand-receptor interaction
  • Osteoclast differentiation
Reactions Not Available
GO Classification
Biological Process
negative regulation of inflammatory response to antigenic stimulus
elevation of cytosolic calcium ion concentration
positive regulation of cell death
G-protein coupled receptor signaling pathway
amylin receptor signaling pathway
cross-receptor inhibition within G protein-coupled receptor heterodimer
positive regulation of calcium ion import across plasma membrane
response to amyloid-beta
positive regulation of ERK1 and ERK2 cascade
response to glucocorticoid stimulus
cell surface receptor signaling pathway
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
positive regulation of adenylate cyclase activity
positive regulation of protein kinase B signaling cascade
positive regulation of gene expression
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein kinase A signaling cascade
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
plasma membrane
amylin receptor complex 2
amylin receptor complex 3
amylin receptor complex 1
axon
integral to plasma membrane
Molecular Function
beta-amyloid binding
calcitonin gene-related peptide receptor activity
amylin receptor activity
calcitonin binding
calcitonin receptor activity
G-protein coupled peptide receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 474
Molecular Weight 55328.135
Theoretical pI 8.289
Pfam Domain Function
Signals
  • 1-24;
Transmembrane Regions
  • 153-173;187-207;234-254;259-279;297-317;341-361;374-394;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P30988
UniProtKB/Swiss-Prot Entry Name CALCR_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  19. Hebden C, Smalt R, Chambers T, Pondel MD: Multiple promoters regulate human calcitonin receptor gene expression. Biochem Biophys Res Commun. 2000 Jun 16;272(3):738-43. doi: 10.1006/bbrc.2000.2842. [PubMed:10860825 ]
  20. Qi T, Dong M, Watkins HA, Wootten D, Miller LJ, Hay DL: Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function. Br J Pharmacol. 2013 Feb;168(3):644-57. doi: 10.1111/j.1476-5381.2012.02197.x. [PubMed:22946511 ]