| Identification |
|---|
| HMDB Protein ID
| HMDBP12710 |
| Secondary Accession Numbers
| None |
| Name
| VIP peptides |
| Synonyms
|
Not Available
|
| Gene Name
| VIP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHI also causes vasodilation. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of protein catabolic process |
| learning or memory |
| negative regulation of apoptotic process |
| phospholipase C-activating G-protein coupled receptor signaling pathway |
| regulation of protein localization |
| mRNA stabilization |
| prolactin secretion |
| epinephrine secretion |
| positive regulation of epinephrine secretion |
| positive regulation of penile erection |
| negative regulation of smooth muscle cell proliferation |
| negative regulation of potassium ion transport |
| regulation of sensory perception of pain |
| positive regulation of endothelial cell proliferation |
| adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| Cellular Component |
| perikaryon |
| extracellular region |
| neuron projection |
| Molecular Function |
| hormone activity |
| neuropeptide hormone activity |
| peptide hormone receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P01284 |
| UniProtKB/Swiss-Prot Entry Name
| VIP_PIG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tatemoto K, Mutt V: Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon--secretin family. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6603-7. doi: 10.1073/pnas.78.11.6603. [PubMed:6947244 ]
- Ichiki Y, Kitamura K, Kangawa K, Kawamoto M, Matsuo H, Eto T: Organ distribution and characterization of porcine peptides (VIP, CGRP and PHI) that increase cAMP in rat platelets. Biochem Biophys Res Commun. 1992 Sep 30;187(3):1587-93. doi: 10.1016/0006-291x(92)90484-3. [PubMed:1329741 ]
- Gafvelin G, Andersson M, Dimaline R, Jornvall H, Mutt V: Isolation and characterization of a variant form of vasoactive intestinal polypeptide. Peptides. 1988 May-Jun;9(3):469-74. doi: 10.1016/0196-9781(88)90149-0. [PubMed:2843830 ]
- Bodanszky M, Klausner YS, Lin CY, Mutt V, Said SI: Synthesis of the vasoactive intestinal peptide (VIP). J Am Chem Soc. 1974 Jul 24;96(15):4973-8. doi: 10.1021/ja00822a041. [PubMed:4854585 ]
|
