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Showing Protein VIP peptides (HMDBP12711)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12711
Secondary Accession Numbers None
Name VIP peptides
Synonyms Not Available
Gene Name VIP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHI also causes vasodilation.
Pathways
  • cAMP signaling pathway
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
positive regulation of protein catabolic process
learning or memory
negative regulation of apoptotic process
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of protein localization
mRNA stabilization
prolactin secretion
epinephrine secretion
positive regulation of epinephrine secretion
positive regulation of penile erection
regulation of signal transduction
negative regulation of smooth muscle cell proliferation
negative regulation of potassium ion transport
regulation of sensory perception of pain
positive regulation of endothelial cell proliferation
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
perikaryon
extracellular region
neuronal cell body
neuron projection
Molecular Function
receptor binding
hormone activity
neuropeptide hormone activity
peptide hormone receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 170
Molecular Weight 19079.155
Theoretical pI 6.045
Pfam Domain Function
Signals
  • 1-21;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P01283
UniProtKB/Swiss-Prot Entry Name VIP_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871. [PubMed:22673903 ]
  2. Lamperti ED, Rosen KM, Villa-Komaroff L: Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse. Brain Res Mol Brain Res. 1991 Feb;9(3):217-31. doi: 10.1016/0169-328x(91)90005-i. [PubMed:1851524 ]
  3. Wershil BK, Turck CW, Sreedharan SP, Yang J, An S, Galli SJ, Goetzl EJ: Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells. Cell Immunol. 1993 Oct 15;151(2):369-78. doi: 10.1006/cimm.1993.1246. [PubMed:8402943 ]
  4. Giladi E, Shani Y, Gozes I: The complete structure of the rat VIP gene. Brain Res Mol Brain Res. 1990 Apr;7(3):261-7. doi: 10.1016/0169-328x(90)90036-d. [PubMed:2159586 ]
  5. Nishizawa M, Hayakawa Y, Yanaihara N, Okamoto H: Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat. FEBS Lett. 1985 Apr 8;183(1):55-9. doi: 10.1016/0014-5793(85)80953-4. [PubMed:3838518 ]
  6. Goetzl EJ, Sreedharan SP, Turck CW: Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells. J Biol Chem. 1988 Jul 5;263(19):9083-6. [PubMed:3379062 ]