Hmdb loader
Identification
HMDB Protein ID HMDBP12723
Secondary Accession Numbers None
Name Cerebellin-1
Synonyms
  1. Precerebellin
Gene Name CBLN1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity).The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of excitatory postsynaptic membrane potential
nervous system development
heterophilic cell-cell adhesion
maintenance of synapse structure
cerebellar granule cell differentiation
negative regulation of inhibitory synapse assembly
positive regulation of long-term synaptic depression
synapse organization
protein secretion
regulation of presynapse assembly
synaptic transmission
positive regulation of synapse assembly
regulation of postsynaptic density assembly
Cellular Component
postsynaptic membrane
synaptic cleft
extracellular region
glutamatergic synapse
collagen-containing extracellular matrix
parallel fiber to Purkinje cell synapse
Molecular Function
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 193
Molecular Weight 21097.0
Theoretical pI 7.288
Pfam Domain Function
Signals
  • 1-21;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P23435
UniProtKB/Swiss-Prot Entry Name CBLN1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Yiangou Y, Burnet P, Nikou G, Chrysanthou BJ, Bloom SR: Purification and characterisation of cerebellins from human and porcine cerebellum. J Neurochem. 1989 Sep;53(3):886-9. doi: 10.1111/j.1471-4159.1989.tb11787.x. [PubMed:2760624 ]
  4. Urade Y, Oberdick J, Molinar-Rode R, Morgan JI: Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):1069-73. doi: 10.1073/pnas.88.3.1069. [PubMed:1704129 ]
  5. Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR: Structural basis for integration of GluD receptors within synaptic organizer complexes. Science. 2016 Jul 15;353(6296):295-9. doi: 10.1126/science.aae0104. [PubMed:27418511 ]