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Identification
HMDB Protein ID HMDBP12750
Secondary Accession Numbers None
Name Integrin-linked protein kinase
Synonyms
  1. 59 kDa serine/threonine-protein kinase
  2. Beta-integrin-linked kinase
  3. ILK-1
  4. ILK-2
  5. p59ILK
Gene Name ILK
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Pathways
  • Axon guidance
  • Bacterial invasion of epithelial cells
  • Endometrial cancer
  • Focal adhesion
  • PPAR signaling pathway
Reactions Not Available
GO Classification
Biological Process
negative regulation of neural precursor cell proliferation
regulation of cell growth
peptidyl-serine phosphorylation
positive regulation of canonical Wnt receptor signaling pathway
substrate adhesion-dependent cell spreading
positive regulation of cell migration
positive regulation of phosphorylation
cell cycle arrest
negative regulation of neuron apoptotic process
positive regulation of cell proliferation
negative regulation of apoptotic process
integrin-mediated signaling pathway
regulation of actin cytoskeleton organization
positive regulation of axon extension
positive regulation of protein phosphorylation
protein kinase B signaling cascade
cell morphogenesis
cell aging
positive regulation of transcription, DNA-dependent
positive regulation of dendrite morphogenesis
positive regulation of protein kinase B signaling cascade
branching involved in ureteric bud morphogenesis
outflow tract morphogenesis
establishment or maintenance of epithelial cell apical/basal polarity
protein phosphorylation
myelin assembly
negative regulation of smooth muscle cell proliferation
myelination in peripheral nervous system
negative regulation of cardiac muscle cell apoptotic process
negative regulation of smooth muscle cell migration
nerve development
positive regulation of axonogenesis
positive regulation of BMP signaling pathway
positive regulation of cell-matrix adhesion
positive regulation of MAPK cascade
positive regulation of osteoblast differentiation
positive regulation of signal transduction
Schwann cell development
supramolecular fiber organization
tumor necrosis factor-mediated signaling pathway
fibroblast migration
positive regulation of myoblast differentiation
neuron projection morphogenesis
cell projection organization
positive regulation of MAP kinase activity
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of NIK/NF-kappaB signaling
negative regulation of protein kinase activity
cell-matrix adhesion
Cellular Component
protein-containing complex
focal adhesion
cytoplasm
plasma membrane
terminal button
cell-cell junction
nucleoplasm
lamellipodium
neuronal cell body
costamere
sarcomere
stress fiber
axon
dendritic shaft
Molecular Function
protein kinase binding
protein-containing complex binding
ATP binding
SH3 domain binding
integrin binding
protein serine kinase activity
protein kinase activity
protein serine/threonine kinase activity
protein threonine kinase activity
protein domain specific binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 452
Molecular Weight 51372.795
Theoretical pI 8.08
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O55222
UniProtKB/Swiss-Prot Entry Name ILK_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  3. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001. [PubMed:23806337 ]
  4. Li F, Liu J, Mayne R, Wu C: Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim Biophys Acta. 1997 Oct 11;1358(3):215-20. doi: 10.1016/s0167-4889(97)00089-x. [PubMed:9366252 ]
  5. Mori K, Asakawa M, Hayashi M, Imura M, Ohki T, Hirao E, Kim-Kaneyama JR, Nose K, Shibanuma M: Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex. J Biol Chem. 2006 Aug 4;281(31):22048-22061. doi: 10.1074/jbc.M513111200. Epub 2006 May 31. [PubMed:16737959 ]
  6. Matsuda C, Kameyama K, Suzuki A, Mishima W, Yamaji S, Okamoto H, Nishino I, Hayashi YK: Affixin activates Rac1 via betaPIX in C2C12 myoblast. FEBS Lett. 2008 Apr 9;582(8):1189-96. doi: 10.1016/j.febslet.2008.01.064. Epub 2008 Mar 4. [PubMed:18325335 ]
  7. Montanez E, Ussar S, Schifferer M, Bosl M, Zent R, Moser M, Fassler R: Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008 May 15;22(10):1325-30. doi: 10.1101/gad.469408. [PubMed:18483218 ]