Hmdb loader
Identification
HMDB Protein ID HMDBP12754
Secondary Accession Numbers None
Name Melanocortin-2 receptor accessory protein 2
Synonyms
  1. MC2R accessory protein 2
Gene Name MRAP2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
feeding behavior
protein localization to plasma membrane
energy homeostasis
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of protein localization to plasma membrane
energy reserve metabolic process
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
plasma membrane
integral to membrane
Molecular Function
corticotropin hormone receptor binding
signaling receptor regulator activity
type 1 melanocortin receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding
type 5 melanocortin receptor binding
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 205
Molecular Weight 23548.08
Theoretical pI 5.007
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 45-65;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96G30
UniProtKB/Swiss-Prot Entry Name MRAP2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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