| Identification |
|---|
| HMDB Protein ID
| HMDBP12757 |
| Secondary Accession Numbers
| None |
| Name
| Pro-opiomelanocortin |
| Synonyms
|
- POMC
- Corticotropin-lipotropin
|
| Gene Name
| POMC |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Stimulates the adrenal glands to release cortisol.Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.Increases the pigmentation of skin by increasing melanin production in melanocytes.Endogenous orexigenic opiate.Endogenous opiate. |
| Pathways
|
- Adipocytokine signaling pathway
- Aldosterone synthesis and secretion
- cAMP signaling pathway
- Cortisol synthesis and secretion
- Cushing syndrome
- Estrogen signaling pathway
- Melanogenesis
- Neuroactive ligand-receptor interaction
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| neuropeptide signaling pathway |
| cortisol secretion |
| regulation of corticosterone secretion |
| Cellular Component |
| secretory granule |
| extracellular space |
| Molecular Function |
| G protein-coupled receptor binding |
| hormone activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 267 |
| Molecular Weight
| 28894.3 |
| Theoretical pI
| 8.508 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P01192 |
| UniProtKB/Swiss-Prot Entry Name
| COLI_PIG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Gossard FJ, Chang AC, Cohen SN: Sequence of the cDNA encoding porcine pro-opiomelanocortin. Biochim Biophys Acta. 1986 Feb 24;866(1):68-74. doi: 10.1016/0167-4781(86)90102-8. [PubMed:3753882 ]
- Boileau G, Barbeau C, Jeannotte L, Chretien M, Drouin J: Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of cloned cDNA. Nucleic Acids Res. 1983 Nov 25;11(22):8063-71. doi: 10.1093/nar/11.22.8063. [PubMed:6196724 ]
- Gen K, Hirai T, Kato T, Kato Y: Presence of the same transcript of pro-opiomelanocortin (POMC) genes in the porcine anterior and intermediate pituitary lobes. Mol Cell Endocrinol. 1994 Jul;103(1-2):101-8. doi: 10.1016/0303-7207(94)90075-2. [PubMed:7958386 ]
- Oates E, Herbert E: 5' sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine and two rat forms. J Biol Chem. 1984 Jun 25;259(12):7421-5. [PubMed:6547437 ]
- Graf L: Re-examination of the sequence of the C-terminal tryptic fragment from porcine adrenocorticotropic hormone. Acta Biochim Biophys Acad Sci Hung. 1972;7(4):293-7. [PubMed:4369114 ]
- Voigt K, Stegmaier W, McGregor GP, Rosch H, Seliger H: Isolation and full structural characterisation of six adrenocorticotropin-like peptides from porcine pituitary gland. Identification of three novel fragments of adrenocorticotropin and of two forms of a novel adrenocorticotropin-like peptide. Eur J Biochem. 1990 Nov 26;194(1):225-36. doi: 10.1111/j.1432-1033.1990.tb19447.x. [PubMed:2174774 ]
- HARRIS JI, LERNER AB: Amino-acid sequence of the alpha-melanocyte-stimulating hormone. Nature. 1957 Jun 29;179(4574):1346-7. doi: 10.1038/1791346a0. [PubMed:13451616 ]
- Sajgo C, Graf L, Barat E, Sajgo M: Amino acid sequence of porcine beta-lipotropic hormone. Biochim Biophys Acta. 1971 Jan 19;229(1):276-8. doi: 10.1016/0005-2795(71)90344-8. [PubMed:5543613 ]
- Pankov IuA, Iudaev NA: [Complete amino acid sequence in the molecule of porcine beta-lipotropin]. Biokhimiia. 1972 Sep-Oct;37(5):991-1004. [PubMed:4673865 ]
- HARRIS JI, ROOS P: Amino-acid sequence of a melanophore-stimulating peptide. Nature. 1956 Jul 14;178(4524):90. doi: 10.1038/178090a0. [PubMed:13348631 ]
- Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR: Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature. 1975 Dec 18;258(5536):577-80. doi: 10.1038/258577a0. [PubMed:1207728 ]
- Graf L, Barat E, Patthy A: Isolation of a COOH-terminal beta-lipotropin fragment (residues 61--91) with morphine-like analgesic activity from porcine pituitary glands. Acta Biochim Biophys Acad Sci Hung. 1976;11(2-3):121-2. [PubMed:1007884 ]
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