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Showing Protein Pro-opiomelanocortin (HMDBP12759)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12759
Secondary Accession Numbers None
Name Pro-opiomelanocortin
Synonyms
  1. POMC
  2. Corticotropin-lipotropin
Gene Name POMC
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Stimulates the adrenal glands to release cortisol.Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.Increases the pigmentation of skin by increasing melanin production in melanocytes.Endogenous orexigenic opiate.Endogenous opiate.
Pathways
  • Adipocytokine signaling pathway
  • Aldosterone synthesis and secretion
  • cAMP signaling pathway
  • Cortisol synthesis and secretion
  • Cushing syndrome
  • Estrogen signaling pathway
  • Melanogenesis
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
signal transduction
cell-cell signaling
negative regulation of inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway
negative regulation of tumor necrosis factor production
neuropeptide signaling pathway
generation of precursor metabolites and energy
glucose homeostasis
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of transcription from RNA polymerase II promoter
cytokine-mediated signaling pathway
regulation of blood pressure
killing of cells of other organism
regulation of corticosterone secretion
cellular pigmentation
modulation of process of other organism
positive regulation of neutrophil mediated killing of fungus
regulation of appetite
regulation of glycogen metabolic process
Cellular Component
cytoplasm
secretory granule
peroxisomal matrix
extracellular region
extracellular space
secretory granule lumen
Molecular Function
G protein-coupled receptor binding
receptor binding
hormone activity
type 1 melanocortin receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 267
Molecular Weight 29423.72
Theoretical pI 7.65
Pfam Domain Function
Signals
  • 1-26;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P01189
UniProtKB/Swiss-Prot Entry Name COLI_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  8. Golovin SIa, Karginov VA, Bondar' AA, Beklemishev AB, Chekhranova MK: [Synthesis, cloning and primary structure of DNA complementary to mRNA for human pituitary pro-opiomelanocortin]. Bioorg Khim. 1987 Apr;13(4):562-4. [PubMed:3606677 ]
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  22. Morris JC, Savva D, Lowry PJ: Reduced expression of a naturally deleted form of human proopiomelanocortin complementary deoxyribonucleic acid after transfection into Chinese hamster ovary cells. Endocrinology. 1995 Jan;136(1):195-201. doi: 10.1210/endo.136.1.7828531. [PubMed:7828531 ]
  23. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998 Jun;19(2):155-7. doi: 10.1038/509. [PubMed:9620771 ]
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  26. Echwald SM, Sorensen TI, Andersen T, Tybjaerg-Hansen A, Clausen JO, Pedersen O: Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity. Int J Obes Relat Metab Disord. 1999 Mar;23(3):293-8. doi: 10.1038/sj.ijo.0800814. [PubMed:10193875 ]
  27. Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S: A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet. 2002 Aug 15;11(17):1997-2004. doi: 10.1093/hmg/11.17.1997. [PubMed:12165561 ]