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Showing Protein Transcriptional regulator Kaiso (HMDBP12763)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12763
Secondary Accession Numbers None
Name Transcriptional regulator Kaiso
Synonyms
  1. Zinc finger and BTB domain-containing protein 33
Gene Name ZBTB33
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
Wnt receptor signaling pathway
regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-dependent
intracellular signal transduction
Cellular Component
cytosol
nucleolus
plasma membrane
nucleus
nucleoplasm
chromatin
Molecular Function
metal ion binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
sequence-specific DNA binding
methyl-CpG binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 672
Molecular Weight 74483.765
Theoretical pI 5.118
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q86T24
UniProtKB/Swiss-Prot Entry Name KAISO_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  8. Daniel JM, Reynolds AB: The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999 May;19(5):3614-23. doi: 10.1128/MCB.19.5.3614. [PubMed:10207085 ]
  9. Kelly KF, Otchere AA, Graham M, Daniel JM: Nuclear import of the BTB/POZ transcriptional regulator Kaiso. J Cell Sci. 2004 Dec 1;117(Pt 25):6143-52. doi: 10.1242/jcs.01541. [PubMed:15564377 ]
  10. Spring CM, Kelly KF, O'Kelly I, Graham M, Crawford HC, Daniel JM: The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res. 2005 May 1;305(2):253-65. doi: 10.1016/j.yexcr.2005.01.007. [PubMed:15817151 ]
  11. Prokhortchouk A, Hendrich B, Jorgensen H, Ruzov A, Wilm M, Georgiev G, Bird A, Prokhortchouk E: The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev. 2001 Jul 1;15(13):1613-8. doi: 10.1101/gad.198501. [PubMed:11445535 ]
  12. Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J: N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell. 2003 Sep;12(3):723-34. doi: 10.1016/j.molcel.2003.08.008. [PubMed:14527417 ]
  13. Ruzov A, Dunican DS, Prokhortchouk A, Pennings S, Stancheva I, Prokhortchouk E, Meehan RR: Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. Development. 2004 Dec;131(24):6185-94. doi: 10.1242/dev.01549. Epub 2004 Nov 17. [PubMed:15548582 ]
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