Hmdb loader
Identification
HMDB Protein ID HMDBP12779
Secondary Accession Numbers None
Name Deubiquitinase OTUD6B
Synonyms
  1. DUBA-5
  2. OTU domain-containing protein 6B
Gene Name OTUD6B
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629).Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
proteasome assembly
protein deubiquitination
cell proliferation
negative regulation of translation
positive regulation of translation
Molecular Function
thiol-dependent deubiquitinase
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 293
Molecular Weight 33812.38
Theoretical pI 6.052
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8N6M0
UniProtKB/Swiss-Prot Entry Name OTU6B_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  10. Xu Z, Zheng Y, Zhu Y, Kong X, Hu L: Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. PLoS One. 2011 Jan 18;6(1):e14514. doi: 10.1371/journal.pone.0014514. [PubMed:21267069 ]
  11. Santiago-Sim T, Burrage LC, Ebstein F, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, Cogne B, Kury S, Besnard T, Isidor B, Bezieau S, Hazart I, Nagakura H, Immken LL, Littlejohn RO, Roeder E, Kara B, Hardies K, Weckhuysen S, May P, Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY, Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg MC, Wells S, Johnson SJ, Teboul L, Eng CM, Yang Y, Kloetzel PM, Heaney JD, Walkiewicz MA: Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. Am J Hum Genet. 2017 Apr 6;100(4):676-688. doi: 10.1016/j.ajhg.2017.03.001. Epub 2017 Mar 23. [PubMed:28343629 ]
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