Hmdb loader
Identification
HMDB Protein ID HMDBP12783
Secondary Accession Numbers None
Name Tight junction protein ZO-3
Synonyms
  1. Tight junction protein 3
  2. Zona occludens protein 3
  3. Zonula occludens protein 3
Gene Name TJP3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).
Pathways
  • Tight junction
Reactions Not Available
GO Classification
Biological Process
cell-cell junction organization
cell-cell adhesion
establishment of endothelial intestinal barrier
maintenance of blood-brain barrier
positive regulation of blood-brain barrier permeability
protein localization to cell-cell junction
Cellular Component
plasma membrane
cell junction
nucleus
nucleoplasm
tight junction
Molecular Function
cell adhesion molecule binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 919
Molecular Weight 101395.98
Theoretical pI 6.752
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95049
UniProtKB/Swiss-Prot Entry Name ZO3_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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