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Showing Protein Parafibromin (HMDBP12787)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12787
Secondary Accession Numbers None
Name Parafibromin
Synonyms
  1. Cell division cycle protein 73 homolog
  2. Hyperparathyroidism 2 protein
Gene Name CDC73
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of cell growth
cell cycle
transcription from RNA polymerase II promoter
beta-catenin-TCF complex assembly
endodermal cell fate commitment
negative regulation of myeloid cell differentiation
positive regulation of cell cycle G1/S phase transition
positive regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
negative regulation of apoptotic process
negative regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
histone H2B ubiquitination
histone monoubiquitination
cellular response to lipopolysaccharide
Wnt receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
mRNA polyadenylation
negative regulation of cell proliferation
stem cell maintenance
transcription elongation from RNA polymerase II promoter
positive regulation of Wnt receptor signaling pathway
protein destabilization
protein ubiquitination
Cellular Component
cytosol
Cdc73/Paf1 complex
nucleus
nucleoplasm
chromosome, telomeric region
Molecular Function
RNA polymerase II core binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 531
Molecular Weight 60576.11
Theoretical pI 9.617
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6P1J9
UniProtKB/Swiss-Prot Entry Name CDC73_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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