Hmdb loader
Identification
HMDB Protein ID HMDBP12796
Secondary Accession Numbers None
Name UV-damage endonuclease
Synonyms
  1. UVDE
Gene Name UVE1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway. Functions also in oxidative damage repair in vivo. Provides back-up AP endonuclease activity to apn2 together with apn1.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
mitochondrial DNA repair
nucleotide-excision repair
mismatch repair
UV-damage excision repair, DNA incision
UV-damage excision repair
pyrimidine dimer repair
base-excision repair
Cellular Component
mitochondrion
nucleus
mitochondrial chromosome
Molecular Function
endonuclease activity
5' deoxyribonuclease (pyrimidine dimer) activity
heteroduplex DNA loop binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 599
Molecular Weight 68815.56
Theoretical pI 8.49
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q10988
UniProtKB/Swiss-Prot Entry Name UVE1_SCHPO
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Takao M, Yonemasu R, Yamamoto K, Yasui A: Characterization of a UV endonuclease gene from the fission yeast Schizosaccharomyces pombe and its bacterial homolog. Nucleic Acids Res. 1996 Apr 1;24(7):1267-71. doi: 10.1093/nar/24.7.1267. [PubMed:8614629 ]
  2. Davey S, Nass ML, Ferrer JV, Sidik K, Eisenberger A, Mitchell DL, Freyer GA: The fission yeast UVDR DNA repair pathway is inducible. Nucleic Acids Res. 1997 Mar 1;25(5):1002-8. doi: 10.1093/nar/25.5.1002. [PubMed:9023111 ]
  3. Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schafer M, Muller-Auer S, Gabel C, Fuchs M, Dusterhoft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sanchez M, del Rey F, Benito J, Dominguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P: The genome sequence of Schizosaccharomyces pombe. Nature. 2002 Feb 21;415(6874):871-80. doi: 10.1038/nature724. [PubMed:11859360 ]
  4. Fraser JL, Neill E, Davey S: Fission yeast Uve1 and Apn2 function in distinct oxidative damage repair pathways in vivo. DNA Repair (Amst). 2003 Nov 21;2(11):1253-67. doi: 10.1016/j.dnarep.2003.08.005. [PubMed:14599746 ]
  5. Ribar B, Izumi T, Mitra S: The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe. Nucleic Acids Res. 2004 Jan 2;32(1):115-26. doi: 10.1093/nar/gkh151. Print 2004. [PubMed:14704348 ]