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Identification
HMDB Protein ID HMDBP12799
Secondary Accession Numbers None
Name DNA repair protein complementing XP-A cells
Synonyms
  1. Xeroderma pigmentosum group A-complementing protein
Gene Name XPA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Pathways
  • Nucleotide excision repair
  • Platinum drug resistance
Reactions Not Available
GO Classification
Biological Process
transcription-coupled nucleotide-excision repair
DNA repair
global genome nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, preincision complex assembly
response to auditory stimulus
nucleotide-excision repair involved in interstrand cross-link repair
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision
nucleotide-excision repair, DNA duplex unwinding
UV-damage excision repair
base-excision repair
UV protection
protein localization to nucleus
Cellular Component
cytoplasm
nucleus
nucleoplasm
nucleotide-excision repair factor 1 complex
intercellular bridge
Molecular Function
metal ion binding
protein homodimerization activity
damaged DNA binding
protein domain specific binding
sequence-specific double-stranded DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 273
Molecular Weight 31367.71
Theoretical pI 6.731
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P23025
UniProtKB/Swiss-Prot Entry Name XPA_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Kang TH, Lindsey-Boltz LA, Reardon JT, Sancar A: Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4890-5. doi: 10.1073/pnas.0915085107. [PubMed:20304803 ]
  5. Cleaver JE, Thompson LH, Richardson AS, States JC: A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Hum Mutat. 1999;14(1):9-22. [PubMed:10447254 ]
  6. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. [PubMed:22814378 ]
  7. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [PubMed:23186163 ]
  8. Hendriks IA, Lyon D, Young C, Jensen LJ, Vertegaal AC, Nielsen ML: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat Struct Mol Biol. 2017 Mar;24(3):325-336. doi: 10.1038/nsmb.3366. Epub 2017 Jan 23. [PubMed:28112733 ]
  9. Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC: Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol. 2014 Oct;21(10):927-36. doi: 10.1038/nsmb.2890. Epub 2014 Sep 14. [PubMed:25218447 ]
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  11. Satokata I, Iwai K, Matsuda T, Okada Y, Tanaka K: Genomic characterization of the human DNA excision repair-controlling gene XPAC. Gene. 1993 Dec 22;136(1-2):345-8. doi: 10.1016/0378-1119(93)90493-m. [PubMed:8294029 ]
  12. He Z, Henricksen LA, Wold MS, Ingles CJ: RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature. 1995 Apr 6;374(6522):566-9. doi: 10.1038/374566a0. [PubMed:7700386 ]
  13. Topping RS, Myrand SP, Williams BL, Albert JC, States JC: Characterization of the human XPA promoter. Gene. 1995 Dec 12;166(2):341-2. doi: 10.1016/0378-1119(95)00649-4. [PubMed:8543191 ]
  14. Miura N, Miyamoto I, Asahina H, Satokata I, Tanaka K, Okada Y: Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene. J Biol Chem. 1991 Oct 15;266(29):19786-9. [PubMed:1918083 ]
  15. Miyamoto I, Miura N, Niwa H, Miyazaki J, Tanaka K: Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair. J Biol Chem. 1992 Jun 15;267(17):12182-7. [PubMed:1601884 ]
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  18. Pan YR, Lee EY: UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. Cell Cycle. 2009 Feb 15;8(4):655-64. doi: 10.4161/cc.8.4.7844. Epub 2009 Feb 14. [PubMed:19197159 ]
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  20. Buchko GW, Daughdrill GW, de Lorimier R, Rao B K, Isern NG, Lingbeck JM, Taylor JS, Wold MS, Gochin M, Spicer LD, Lowry DF, Kennedy MA: Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. Biochemistry. 1999 Nov 16;38(46):15116-28. doi: 10.1021/bi991755p. [PubMed:10563794 ]
  21. Satokata I, Tanaka K, Okada Y: Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene. Hum Genet. 1992 Mar;88(6):603-7. doi: 10.1007/BF02265282. [PubMed:1339397 ]
  22. Satokata I, Tanaka K, Yuba S, Okada Y: Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum. Mutat Res. 1992 Mar;273(2):203-12. doi: 10.1016/0921-8777(92)90081-d. [PubMed:1372103 ]
  23. States JC, McDuffie ER, Myrand SP, McDowell M, Cleaver JE: Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein. Hum Mutat. 1998;12(2):103-13. doi: 10.1002/(SICI)1098-1004(1998)12:2<103::AID-HUMU5>3.0.CO;2-6. [PubMed:9671271 ]