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Showing Protein Cryptochrome-1 (HMDBP12800)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12800
Secondary Accession Numbers None
Name Cryptochrome-1
Synonyms
  1. DmCRY1
  2. dcry
  3. Blue light photoreceptor
Gene Name CRY
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
entrainment of circadian clock by photoperiod
regulation of circadian sleep/wake cycle, sleep
response to light stimulus
phototransduction
locomotor rhythm
blue light signaling pathway
cellular response to light stimulus
circadian behavior
detection of light stimulus involved in magnetoreception
gravitaxis
magnetoreception
protein-chromophore linkage
response to blue light
response to magnetism
UV-A, blue light phototransduction
negative regulation of transcription, DNA-dependent
regulation of circadian rhythm
circadian regulation of gene expression
entrainment of circadian clock
circadian rhythm
Cellular Component
cytosol
cytoplasm
perinuclear region of cytoplasm
nucleus
nucleoplasm
Molecular Function
G-protein coupled photoreceptor activity
blue light photoreceptor activity
photoreceptor activity
FAD binding
flavin adenine dinucleotide binding
DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 542
Molecular Weight 62512.095
Theoretical pI 6.33
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O77059
UniProtKB/Swiss-Prot Entry Name CRY1_DROME
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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