| Identification |
|---|
| HMDB Protein ID
| HMDBP12804 |
| Secondary Accession Numbers
| None |
| Name
| Taste receptor type 2 member 105 |
| Synonyms
|
- T2R105
- Taste receptor type 2 member 9
- T2R9
|
| Gene Name
| TAS2R105 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| detection of chemical stimulus involved in sensory perception of bitter taste |
| Cellular Component |
| integral to membrane |
| Molecular Function |
| taste receptor activity |
| G protein-coupled receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35148.67 |
| Theoretical pI
| 9.549 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 10-32;45-67;87-109;130-149;178-200;227-249;259-281;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9JKT5 |
| UniProtKB/Swiss-Prot Entry Name
| TR105_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS: A novel family of mammalian taste receptors. Cell. 2000 Mar 17;100(6):693-702. [PubMed:10761934 ]
- Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ: T2Rs function as bitter taste receptors. Cell. 2000 Mar 17;100(6):703-11. [PubMed:10761935 ]
- Montmayeur JP, Matsunami H: Receptors for bitter and sweet taste. Curr Opin Neurobiol. 2002 Aug;12(4):366-71. [PubMed:12139982 ]
- Margolskee RF: Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem. 2002 Jan 4;277(1):1-4. Epub 2001 Nov 5. [PubMed:11696554 ]
- Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003 Feb 7;112(3):293-301. [PubMed:12581520 ]
- Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W: The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002 Nov;32(3):397-401. Epub 2002 Oct 15. [PubMed:12379855 ]
- Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E: Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2392-7. doi: 10.1073/pnas.042617699. [PubMed:11854532 ]
|
