Hmdb loader

Showing Protein Major facilitator superfamily multidrug transporter FLU1 (HMDBP12806)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12806
Secondary Accession Numbers None
Name Major facilitator superfamily multidrug transporter FLU1
Synonyms
  1. Fluconazole resistance protein 1
Gene Name FLU1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Major facilitator superfamily transporter that mediates resistance to structurally and functionally unrelated compounds including cycloheximide but also azoles such as fuconazole, ketoconazole and itraconazole (PubMed:11065353, PubMed:11181345). Mediates also efflux of histatin 5, a salivary human antimicrobial peptide, and is responsible for reduction of its toxicity in C.albicans (PubMed:23380720, PubMed:28953977).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
spermidine transport
peptide transport
fluconazole transport
xenobiotic detoxification by transmembrane export across the plasma membrane
Cellular Component
plasma membrane
integral to membrane
Molecular Function
xenobiotic transporter activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 610
Molecular Weight 67605.895
Theoretical pI 6.658
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 165-185;209-229;231-251;262-282;292-312;323-343;408-428;437-457;478-498;507-527;530-550;573-593;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID G1UB37
UniProtKB/Swiss-Prot Entry Name FLU1_CANAL
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
  2. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
  3. Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
  4. Calabrese D, Bille J, Sanglard D: A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole. Microbiology (Reading). 2000 Nov;146 ( Pt 11):2743-2754. doi: 10.1099/00221287-146-11-2743. [PubMed:11065353 ]
  5. Chibana H, Oka N, Nakayama H, Aoyama T, Magee BB, Magee PT, Mikami Y: Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome. Genetics. 2005 Aug;170(4):1525-37. doi: 10.1534/genetics.104.034652. Epub 2005 Jun 3. [PubMed:15937140 ]
  6. Marchetti O, Majcherczyk PA, Glauser MP, Bille J, Moreillon P, Sanglard D: Sensitive bioassay for determination of fluconazole concentrations in plasma using a Candida albicans mutant hypersusceptible to azoles. Antimicrob Agents Chemother. 2001 Mar;45(3):696-700. doi: 10.1128/AAC.45.3.696-700.2001. [PubMed:11181345 ]
  7. Znaidi S, Barker KS, Weber S, Alarco AM, Liu TT, Boucher G, Rogers PD, Raymond M: Identification of the Candida albicans Cap1p regulon. Eukaryot Cell. 2009 Jun;8(6):806-20. doi: 10.1128/EC.00002-09. Epub 2009 Apr 24. [PubMed:19395663 ]
  8. Zhang H, Gao A, Li F, Zhang G, Ho HI, Liao W: Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps. Yakugaku Zasshi. 2009 May;129(5):623-30. doi: 10.1248/yakushi.129.623. [PubMed:19420894 ]
  9. Li R, Kumar R, Tati S, Puri S, Edgerton M: Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity. Antimicrob Agents Chemother. 2013 Apr;57(4):1832-9. doi: 10.1128/AAC.02295-12. Epub 2013 Feb 4. [PubMed:23380720 ]
  10. Guo H, Zhang XL, Gao LQ, Li SX, Song YJ, Zhang H: Alcohol dehydrogenase I expression correlates with CDR1, CDR2 and FLU1 expression in Candida albicans from patients with vulvovaginal candidiasis. Chin Med J (Engl). 2013;126(11):2098-102. [PubMed:23769565 ]
  11. Zhang JY, Liu JH, Liu FD, Xia YH, Wang J, Liu X, Zhang ZQ, Zhu N, Yan-Yan, Ying Y, Huang XT: Vulvovaginal candidiasis: species distribution, fluconazole resistance and drug efflux pump gene overexpression. Mycoses. 2014 Oct;57(10):584-91. doi: 10.1111/myc.12204. [PubMed:24962255 ]
  12. Hampe IAI, Friedman J, Edgerton M, Morschhauser J: An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses. PLoS Pathog. 2017 Sep 27;13(9):e1006655. doi: 10.1371/journal.ppat.1006655. eCollection 2017 Sep. [PubMed:28953977 ]