| Specific Function
| Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump represents also an detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine. |
| General References
| - Burmester A, Shelest E, Glockner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wostemeyer J, Zipfel PF, Monod M, Brakhage AA: Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol. 2011;12(1):R7. doi: 10.1186/gb-2011-12-1-r7. Epub 2011 Jan 19. [PubMed:21247460 ]
- Lechenne B, Reichard U, Zaugg C, Fratti M, Kunert J, Boulat O, Monod M: Sulphite efflux pumps in Aspergillus fumigatus and dermatophytes. Microbiology (Reading). 2007 Mar;153(Pt 3):905-913. doi: 10.1099/mic.0.2006/003335-0. [PubMed:17322211 ]
- Grumbt M, Monod M, Yamada T, Hertweck C, Kunert J, Staib P: Keratin degradation by dermatophytes relies on cysteine dioxygenase and a sulfite efflux pump. J Invest Dermatol. 2013 Jun;133(6):1550-5. doi: 10.1038/jid.2013.41. Epub 2013 Jan 25. [PubMed:23353986 ]
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