| Identification |
|---|
| HMDB Protein ID
| HMDBP12818 |
| Secondary Accession Numbers
| None |
| Name
| Cystine transporter |
| Synonyms
|
- ERD suppressor
- Transmembrane protein ERS1
|
| Gene Name
| ERS1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from vacuoles/endodomes. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| L-cystine transport |
| Cellular Component |
| plasma membrane |
| vacuolar membrane |
| fungal-type vacuole |
| endosome membrane |
| integral to membrane |
| endosome |
| Molecular Function |
| L-cystine transmembrane transporter activity |
| symporter activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 260 |
| Molecular Weight
| 30116.035 |
| Theoretical pI
| 8.707 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 7-28;40-62;81-102;118-138;151-175;185-205;227-247;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P17261 |
| UniProtKB/Swiss-Prot Entry Name
| ERS1_YEAST |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995. [PubMed:24374639 ]
- Hardwick KG, Pelham HR: ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiae. Nucleic Acids Res. 1990 Apr 25;18(8):2177. doi: 10.1093/nar/18.8.2177. [PubMed:2186379 ]
- Oliver SG, van der Aart QJ, Agostoni-Carbone ML, Aigle M, Alberghina L, Alexandraki D, Antoine G, Anwar R, Ballesta JP, Benit P, et al.: The complete DNA sequence of yeast chromosome III. Nature. 1992 May 7;357(6373):38-46. doi: 10.1038/357038a0. [PubMed:1574125 ]
- Gao XD, Wang J, Keppler-Ross S, Dean N: ERS1 encodes a functional homologue of the human lysosomal cystine transporter. FEBS J. 2005 May;272(10):2497-511. doi: 10.1111/j.1742-4658.2005.04670.x. [PubMed:15885099 ]
|
