Hmdb loader
Identification
HMDB Protein ID HMDBP12819
Secondary Accession Numbers None
Name Major facilitator superfamily domain-containing protein 12
Synonyms Not Available
Gene Name MFSD12
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells (PubMed:33208952).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
melanin biosynthetic process
cysteine transmembrane transport
negative regulation of melanin biosynthetic process
pigment metabolic process involved in pigmentation
regulation of melanin biosynthetic process
carbohydrate transport
organic substance transport
Cellular Component
melanosome membrane
melanosome
lysosome
late endosome
lysosomal membrane
integral to plasma membrane
Molecular Function
cysteine transmembrane transporter activity
symporter activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 480
Molecular Weight 52074.655
Theoretical pI 8.319
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions
  • 27-47;57-77;98-118;125-145;171-191;219-239;280-302;311-331;348-368;369-389;403-423;447-467;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6NUT3
UniProtKB/Swiss-Prot Entry Name MFS12_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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