| Identification |
|---|
| HMDB Protein ID
| HMDBP12850 |
| Secondary Accession Numbers
| None |
| Name
| 3-dehydroquinate dehydratase |
| Synonyms
|
- 3-dehydroquinase
- Type I DHQase
- Type I dehydroquinase
- DHQ1
|
| Gene Name
| AROD |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of Lys-170 at the active site. |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- chorismate biosynthesis
- Phenylalanine, tyrosine and tryptophan biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cellular amino acid biosynthetic process |
| aromatic amino acid family biosynthetic process |
| chorismate biosynthetic process |
| 3,4-dihydroxybenzoate biosynthetic process |
| Molecular Function |
| 3-dehydroquinate dehydratase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 255 |
| Molecular Weight
| 28875.51 |
| Theoretical pI
| 6.57 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q186A6 |
| UniProtKB/Swiss-Prot Entry Name
| AROD_CLOD6 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeno-Tarraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, Sharp S, Simmonds M, Stevens K, Unwin L, Whithead S, Dupuy B, Dougan G, Barrell B, Parkhill J: The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet. 2006 Jul;38(7):779-86. Epub 2006 Jun 25. [PubMed:16804543 ]
- Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A: Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates. J Biol Chem. 2011 Feb 4;286(5):3531-9. doi: 10.1074/jbc.M110.192831. Epub 2010 Nov 18. [PubMed:21087925 ]
|
