Hmdb loader
Identification
HMDB Protein ID HMDBP13076
Secondary Accession Numbers None
Name Triosephosphate isomerase
Synonyms
  1. TIM
  2. Methylglyoxal synthase
  3. Triose-phosphate isomerase
Gene Name TPI1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
Pathways
  • Biosynthesis of amino acids
  • Carbon metabolism
  • Fructose and mannose metabolism
  • gluconeogenesis
  • glycolysis
  • Glycolysis / Gluconeogenesis
  • Inositol phosphate metabolism
Reactions Not Available
GO Classification
Biological Process
multicellular organismal development
glycolysis
methylglyoxal biosynthetic process
gluconeogenesis
glucose metabolic process
glycerol catabolic process
glyceraldehyde-3-phosphate metabolic process
glyceraldehyde-3-phosphate biosynthetic process
Cellular Component
cytosol
Molecular Function
triose-phosphate isomerase activity
ubiquitin protein ligase binding
protein homodimerization activity
methylglyoxal synthase activity
isomerase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 249
Molecular Weight 26712.47
Theoretical pI 7.305
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P17751
UniProtKB/Swiss-Prot Entry Name TPIS_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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