Hmdb loader
Identification
HMDB Protein ID HMDBP13149
Secondary Accession Numbers None
Name Damage-control phosphatase ARMT1
Synonyms
  1. Acidic residue methyltransferase 1
  2. Protein-glutamate O-methyltransferase
  3. Sugar phosphate phosphatase ARMT1
Gene Name ARMT1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
response to DNA damage stimulus
regulation of response to DNA damage stimulus
methylation
Molecular Function
metal ion binding
S-adenosylmethionine-dependent methyltransferase activity
phosphatase activity
enzyme binding
fructose 6-phosphate aldolase activity
fructose-1-phosphatase activity
protein carboxyl O-methyltransferase activity
protein-glutamate O-methyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 439
Molecular Weight 50548.33
Theoretical pI 5.918
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A6H630
UniProtKB/Swiss-Prot Entry Name ARMT1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
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