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Identification
HMDB Protein ID HMDBP13203
Secondary Accession Numbers None
Name 1-deoxy-D-xylulose-5-phosphate synthase
Synonyms
  1. 1-deoxyxylulose-5-phosphate synthase
  2. DXP synthase
  3. DXPS
Gene Name DXS
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Pathways
  • 1-deoxy-D-xylulose 5-phosphate biosynthesis
  • Biosynthesis of secondary metabolites
  • Terpenoid backbone biosynthesis
  • Thiamine metabolism
Reactions Not Available
GO Classification
Biological Process
thiamine biosynthetic process
1-deoxy-D-xylulose 5-phosphate biosynthetic process
terpenoid biosynthetic process
Molecular Function
magnesium ion binding
1-deoxy-D-xylulose-5-phosphate synthase activity
thiamine pyrophosphate binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 615
Molecular Weight 67321.71
Theoretical pI 6.835
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A0Q6B9
UniProtKB/Swiss-Prot Entry Name DXS_FRATN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Rohmer L, Fong C, Abmayr S, Wasnick M, Larson Freeman TJ, Radey M, Guina T, Svensson K, Hayden HS, Jacobs M, Gallagher LA, Manoil C, Ernst RK, Drees B, Buckley D, Haugen E, Bovee D, Zhou Y, Chang J, Levy R, Lim R, Gillett W, Guenthener D, Kang A, Shaffer SA, Taylor G, Chen J, Gallis B, D'Argenio DA, Forsman M, Olson MV, Goodlett DR, Kaul R, Miller SI, Brittnacher MJ: Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol. 2007;8(6):R102. doi: 10.1186/gb-2007-8-6-r102. [PubMed:17550600 ]