Hmdb loader
Identification
HMDB Protein ID HMDBP13349
Secondary Accession Numbers None
Name Aflatoxin B1 aldehyde reductase member 2
Synonyms
  1. Succinic semialdehyde reductase
  2. SSA reductase
Gene Name AKR7A2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).
Pathways
  • Metabolism of xenobiotics by cytochrome P450
Reactions Not Available
GO Classification
Biological Process
daunorubicin metabolic process
doxorubicin metabolic process
Cellular Component
cytosol
cytoplasm
mitochondrion
Golgi apparatus
nuclear envelope
Molecular Function
alditol:NADP+ 1-oxidoreductase activity
D-threo-aldose 1-dehydrogenase activity
phenanthrene-9,10-epoxide hydrolase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 367
Molecular Weight 40611.79
Theoretical pI 8.12
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8CG76
UniProtKB/Swiss-Prot Entry Name ARK72_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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