| Identification |
|---|
| HMDB Protein ID
| HMDBP13361 |
| Secondary Accession Numbers
| None |
| Name
| Gamma conglutin 1 |
| Synonyms
|
- Conglutin gamma 32
|
| Gene Name
| CGAMMA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Sulfur-rich seed storage protein that remains undegraded at germination (PubMed:11406286). The uncleaved form exhibits some inhibitory activity against GH11 xylanase from T.longibrachiatum, more at pH 7 than at pH 5.3, but not against GH12 xyloglucan-specific endoglucanase (XEG) from A.aculeatus (PubMed:26741537). Binds to model phospholipid membranes containing dimyristoyl phosphatidylglycerol (DMPG), dioleoyl phosphatidic acid (DOPA) or mixture of dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol (DMPC:DMPG), or mixture of dioleoyl phosphatidic acid and dioleoyl phosphatidylcholine (DOPC:DOPA) (PubMed:30312772). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of catalytic activity |
| Cellular Component |
| extracellular space |
| Molecular Function |
| protein self-association |
| aspartic-type endopeptidase activity |
| enzyme inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 49218.585 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9FSH9 |
| UniProtKB/Swiss-Prot Entry Name
| CONG1_LUPAL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Scarafoni A, Di Cataldo A, Vassilevskaia TD, Bekman EP, Rodrigues-Pousada C, Ceciliani F, Duranti M: Cloning, sequencing and expression in the seeds and radicles of two Lupinus albus conglutin gamma genes. Biochim Biophys Acta. 2001 May 28;1519(1-2):147-51. doi: 10.1016/s0167-4781(01)00225-1. [PubMed:11406286 ]
- Capraro J, Spotti P, Magni C, Scarafoni A, Duranti M: Spectroscopic studies on the pH-dependent structural dynamics of gamma-conglutin, the blood glucose-lowering protein of lupin seeds. Int J Biol Macromol. 2010 Nov 1;47(4):502-7. doi: 10.1016/j.ijbiomac.2010.07.005. Epub 2010 Jul 27. [PubMed:20670643 ]
- Scarafoni A, Ronchi A, Duranti M: gamma-Conglutin, the Lupinus albus XEGIP-like protein, whose expression is elicited by chitosan, lacks of the typical inhibitory activity against GH12 endo-glucanases. Phytochemistry. 2010 Feb;71(2-3):142-8. doi: 10.1016/j.phytochem.2009.11.001. Epub 2009 Dec 3. [PubMed:19962718 ]
- Bertoglio JC, Calvo MA, Hancke JL, Burgos RA, Riva A, Morazzoni P, Ponzone C, Magni C, Duranti M: Hypoglycemic effect of lupin seed gamma-conglutin in experimental animals and healthy human subjects. Fitoterapia. 2011 Oct;82(7):933-8. doi: 10.1016/j.fitote.2011.05.007. Epub 2011 May 14. [PubMed:21605639 ]
- Lovati MR, Manzoni C, Castiglioni S, Parolari A, Magni C, Duranti M: Lupin seed gamma-conglutin lowers blood glucose in hyperglycaemic rats and increases glucose consumption of HepG2 cells. Br J Nutr. 2012 Jan;107(1):67-73. doi: 10.1017/S0007114511002601. Epub 2011 Jun 28. [PubMed:21733318 ]
- Schiarea S, Arnoldi L, Fanelli R, De Combarieu E, Chiabrando C: In-depth glycoproteomic characterization of gamma-conglutin by high-resolution accurate mass spectrometry. PLoS One. 2013 Sep 12;8(9):e73906. doi: 10.1371/journal.pone.0073906. eCollection 2013. [PubMed:24069245 ]
- Capraro J, Magni C, Scarafoni A, Caramanico R, Rossi F, Morlacchini M, Duranti M: Pasta supplemented with isolated lupin protein fractions reduces body weight gain and food intake of rats and decreases plasma glucose concentration upon glucose overload trial. Food Funct. 2014 Feb;5(2):375-80. doi: 10.1039/c3fo60583c. [PubMed:24394732 ]
- Vargas-Guerrero B, Garcia-Lopez PM, Martinez-Ayala AL, Dominguez-Rosales JA, Gurrola-Diaz CM: Administration of Lupinus albus gamma conglutin (Cgamma) to n5 STZ rats augmented Ins-1 gene expression and pancreatic insulin content. Plant Foods Hum Nutr. 2014 Sep;69(3):241-7. doi: 10.1007/s11130-014-0424-y. [PubMed:24894193 ]
- Scarafoni A, Consonni A, Pessina S, Balzaretti S, Capraro J, Galanti E, Duranti M: Structural basis of the lack of endo-glucanase inhibitory activity of Lupinus albus gamma-conglutin. Plant Physiol Biochem. 2016 Feb;99:79-85. doi: 10.1016/j.plaphy.2015.11.008. Epub 2015 Nov 24. [PubMed:26741537 ]
- Gonzalez-Santiago AE, Vargas-Guerrero B, Garcia-Lopez PM, Martinez-Ayala AL, Dominguez-Rosales JA, Gurrola-Diaz CM: Lupinus albus Conglutin Gamma Modifies the Gene Expressions of Enzymes Involved in Glucose Hepatic Production In Vivo. Plant Foods Hum Nutr. 2017 Jun;72(2):134-140. doi: 10.1007/s11130-016-0597-7. [PubMed:28101822 ]
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