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Identification
HMDB Protein ID HMDBP13374
Secondary Accession Numbers None
Name Cell cycle control protein 50A
Synonyms
  1. P4-ATPase flippase complex beta subunit TMEM30A
  2. Transmembrane protein 30A
Gene Name TMEM30A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
neutrophil degranulation
positive regulation of protein exit from endoplasmic reticulum
aminophospholipid transport
drug transmembrane transport
phospholipid translocation
positive regulation of phospholipid translocation
protein localization to endosome
positive regulation of neuron projection development
Cellular Component
specific granule membrane
endoplasmic reticulum
plasma membrane
Golgi apparatus
azurophil granule membrane
phospholipid-translocating ATPase complex
apical plasma membrane
transport vesicle membrane
membrane
integral to membrane
Molecular Function
aminophospholipid flippase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 361
Molecular Weight 40683.25
Theoretical pI 8.588
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 50-70;326-346;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NV96
UniProtKB/Swiss-Prot Entry Name CC50A_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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