| Identification |
|---|
| HMDB Protein ID
| HMDBP13379 |
| Secondary Accession Numbers
| None |
| Name
| Staphopain A |
| Synonyms
|
- Staphylococcal cysteine proteinase A
- Staphylopain A
|
| Gene Name
| SSPP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cysteine protease that plays an important role in the inhibition of host innate immune response. Cleaves host elastins found in connective tissues, pulmonary surfactant protein A in the lungs, and the chemokine receptor CXCR2 on leukocytes (PubMed:3422637, PubMed:23235402). Proteolytic cleavage of surfactant protein A impairs bacterial phagocytocis by neutrophils while CXCR2 degradation blocks neutrophil activation and chemotaxis (PubMed:3422637, PubMed:23235402). Additionally, promotes vascular leakage by activating the plasma kallikerin/kinin system, resulting in hypotension (PubMed:15897280). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| cysteine-type peptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 44119.665 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P81297 |
| UniProtKB/Swiss-Prot Entry Name
| SSPP_STAAU |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Golonka E, Filipek R, Sabat A, Sinczak A, Potempa J: Genetic characterization of staphopain genes in Staphylococcus aureus. Biol Chem. 2004 Nov;385(11):1059-67. doi: 10.1515/BC.2004.137. [PubMed:15576326 ]
- Potempa J, Dubin A, Korzus G, Travis J: Degradation of elastin by a cysteine proteinase from Staphylococcus aureus. J Biol Chem. 1988 Feb 25;263(6):2664-7. [PubMed:3422637 ]
- Dubin G, Krajewski M, Popowicz G, Stec-Niemczyk J, Bochtler M, Potempa J, Dubin A, Holak TA: A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus. Biochemistry. 2003 Nov 25;42(46):13449-56. doi: 10.1021/bi035310j. [PubMed:14621990 ]
- Imamura T, Tanase S, Szmyd G, Kozik A, Travis J, Potempa J: Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus. J Exp Med. 2005 May 16;201(10):1669-76. doi: 10.1084/jem.20042041. [PubMed:15897280 ]
- Laarman AJ, Mijnheer G, Mootz JM, van Rooijen WJ, Ruyken M, Malone CL, Heezius EC, Ward R, Milligan G, van Strijp JA, de Haas CJ, Horswill AR, van Kessel KP, Rooijakkers SH: Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. EMBO J. 2012 Aug 29;31(17):3607-19. doi: 10.1038/emboj.2012.212. Epub 2012 Jul 31. [PubMed:22850671 ]
- Kantyka T, Pyrc K, Gruca M, Smagur J, Plaza K, Guzik K, Zeglen S, Ochman M, Potempa J: Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung. J Innate Immun. 2013;5(3):251-60. doi: 10.1159/000345417. Epub 2012 Dec 11. [PubMed:23235402 ]
|
