| Identification |
|---|
| HMDB Protein ID
| HMDBP13381 |
| Secondary Accession Numbers
| None |
| Name
| Staphopain B |
| Synonyms
|
- Staphylococcal cysteine proteinase B
- Staphylopain B
|
| Gene Name
| SSPB |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner (PubMed:20375568, PubMed:19284294). Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils (PubMed:19284294). Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin (PubMed:28438975). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| cysteine-type peptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 44575.82 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0C1S6 |
| UniProtKB/Swiss-Prot Entry Name
| SSPB_STAAU |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Golonka E, Filipek R, Sabat A, Sinczak A, Potempa J: Genetic characterization of staphopain genes in Staphylococcus aureus. Biol Chem. 2004 Nov;385(11):1059-67. doi: 10.1515/BC.2004.137. [PubMed:15576326 ]
- Rzychon M, Sabat A, Kosowska K, Potempa J, Dubin A: Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases. Mol Microbiol. 2003 Aug;49(4):1051-66. doi: 10.1046/j.1365-2958.2003.03613.x. [PubMed:12890028 ]
- Smagur J, Guzik K, Magiera L, Bzowska M, Gruca M, Thogersen IB, Enghild JJ, Potempa J: A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes. J Innate Immun. 2009;1(2):98-108. doi: 10.1159/000181014. Epub 2008 Dec 2. [PubMed:20375568 ]
- Smagur J, Guzik K, Bzowska M, Kuzak M, Zarebski M, Kantyka T, Walski M, Gajkowska B, Potempa J: Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages. Biol Chem. 2009 Apr;390(4):361-71. doi: 10.1515/BC.2009.042. [PubMed:19284294 ]
- Filipek R, Rzychon M, Oleksy A, Gruca M, Dubin A, Potempa J, Bochtler M: The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease. J Biol Chem. 2003 Oct 17;278(42):40959-66. doi: 10.1074/jbc.M302926200. Epub 2003 Jul 21. [PubMed:12874290 ]
- Filipek R, Szczepanowski R, Sabat A, Potempa J, Bochtler M: Prostaphopain B structure: a comparison of proregion-mediated and staphostatin-mediated protease inhibition. Biochemistry. 2004 Nov 9;43(44):14306-15. doi: 10.1021/bi048661m. [PubMed:15518582 ]
- Filipek R, Potempa J, Bochtler M: A comparison of staphostatin B with standard mechanism serine protease inhibitors. J Biol Chem. 2005 Apr 15;280(15):14669-74. doi: 10.1074/jbc.M411792200. Epub 2005 Jan 11. [PubMed:15644332 ]
|
