| Identification |
|---|
| HMDB Protein ID
| HMDBP13388 |
| Secondary Accession Numbers
| None |
| Name
| Chymotrypsin-like elastase family member 2A |
| Synonyms
|
- Elastase-2
- Elastase-2A
|
| Gene Name
| CELA2A |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. |
| Pathways
|
- Pancreatic secretion
- Protein digestion and absorption
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| insulin catabolic process |
| response to insulin stimulus |
| regulation of platelet aggregation |
| proteolysis |
| regulation of insulin secretion |
| Cellular Component |
| extracellular region |
| extracellular space |
| Molecular Function |
| endopeptidase activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 269 |
| Molecular Weight
| 28699.3 |
| Theoretical pI
| 8.024 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P08419 |
| UniProtKB/Swiss-Prot Entry Name
| CEL2A_PIG |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kawashima I, Tani T, Shimoda K, Takiguchi Y: Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA. 1987 Apr;6(2):163-72. doi: 10.1089/dna.1987.6.163. [PubMed:3646943 ]
- Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.: Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J Biochem. 1987 Dec;102(6):1555-63. doi: 10.1093/oxfordjournals.jbchem.a122204. [PubMed:2834346 ]
|
