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Showing Protein Extracellular metalloproteinase mep (HMDBP13393)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13393
Secondary Accession Numbers None
Name Extracellular metalloproteinase mep
Synonyms
  1. AfuMep
  2. Allergen Asp f 5
  3. Elastinolytic metalloproteinase mep
  4. Fungalysin mep
Gene Name MEP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Secreted metalloproteinase that allows assimilation of proteinaceous substrates and probably acts as a virulence factor (By similarity). Catalyzes the hydrolysis of elastin (PubMed:7927676, PubMed:8188335). Hydrolyzes azocasein, synthetic fluorigenic substrate Abz-Ala-Ala-Phe-Phe-pNA, and His-Leu, Ala-Leu, Tyr-Leu, Gly-Phe, and Phe-Phe peptide bonds in the B chain of insulin (PubMed:8188335).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
pathogenesis
Cellular Component
extracellular space
Molecular Function
metalloendopeptidase activity
zinc ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 634
Molecular Weight 68707.585
Theoretical pI 5.414
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P46075
UniProtKB/Swiss-Prot Entry Name ELM_ASPFU
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 2005 Dec 22;438(7071):1151-6. doi: 10.1038/nature04332. [PubMed:16372009 ]
  2. Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann S: A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence. Infect Immun. 2009 Sep;77(9):4041-50. doi: 10.1128/IAI.00425-09. Epub 2009 Jun 29. [PubMed:19564390 ]
  3. Sharon H, Hagag S, Osherov N: Transcription factor PrtT controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus. Infect Immun. 2009 Sep;77(9):4051-60. doi: 10.1128/IAI.00426-09. Epub 2009 Jun 29. [PubMed:19564385 ]
  4. Jaton-Ogay K, Paris S, Huerre M, Quadroni M, Falchetto R, Togni G, Latge JP, Monod M: Cloning and disruption of the gene encoding an extracellular metalloprotease of Aspergillus fumigatus. Mol Microbiol. 1994 Dec;14(5):917-28. doi: 10.1111/j.1365-2958.1994.tb01327.x. [PubMed:7715453 ]
  5. Sirakova TD, Markaryan A, Kolattukudy PE: Molecular cloning and sequencing of the cDNA and gene for a novel elastinolytic metalloproteinase from Aspergillus fumigatus and its expression in Escherichia coli. Infect Immun. 1994 Oct;62(10):4208-18. doi: 10.1128/iai.62.10.4208-4218.1994. [PubMed:7927676 ]
  6. Markaryan A, Morozova I, Yu H, Kolattukudy PE: Purification and characterization of an elastinolytic metalloprotease from Aspergillus fumigatus and immunoelectron microscopic evidence of secretion of this enzyme by the fungus invading the murine lung. Infect Immun. 1994 Jun;62(6):2149-57. doi: 10.1128/iai.62.6.2149-2157.1994. [PubMed:8188335 ]
  7. Crameri R: Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications. Int Arch Allergy Immunol. 1998 Feb;115(2):99-114. doi: 10.1159/000023889. [PubMed:9482698 ]
  8. Fernandez D, Russi S, Vendrell J, Monod M, Pallares I: A functional and structural study of the major metalloprotease secreted by the pathogenic fungus Aspergillus fumigatus. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1946-57. doi: 10.1107/S0907444913017642. Epub 2013 Sep 20. [PubMed:24100314 ]