| Identification |
|---|
| HMDB Protein ID
| HMDBP13394 |
| Secondary Accession Numbers
| None |
| Name
| Fibronectin-binding protein B |
| Synonyms
|
Not Available
|
| Gene Name
| FNBB |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Multifunctional protein which promotes bacterial attachment to fibrinogen, elastin and fibronectin (PubMed:15234962, PubMed:21569203, PubMed:27387503). Promotes also the accumulation phase and the primary attachment phase of biofilm formation (PubMed:24628034). In addition, protects against the antimicrobial activity of histones. Mechanistically, captures histones and prevents them from reaching the bacterial membrane and simultaneously binds plasminogen, thereby promoting its conversion to plasmin to destroy the bound histones (PubMed:30622139, PubMed:27387503). |
| Pathways
|
- Bacterial invasion of epithelial cells
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell adhesion |
| pathogenesis |
| Cellular Component |
| extracellular region |
| cell wall |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 940 |
| Molecular Weight
| 103554.575 |
| Theoretical pI
| 4.723 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A0H2XKG3 |
| UniProtKB/Swiss-Prot Entry Name
| FNBB_STAA3 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau-Remington F: Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet. 2006 Mar 4;367(9512):731-9. doi: 10.1016/S0140-6736(06)68231-7. [PubMed:16517273 ]
- Roche FM, Downer R, Keane F, Speziale P, Park PW, Foster TJ: The N-terminal A domain of fibronectin-binding proteins A and B promotes adhesion of Staphylococcus aureus to elastin. J Biol Chem. 2004 Sep 10;279(37):38433-40. doi: 10.1074/jbc.M402122200. Epub 2004 Jul 2. [PubMed:15234962 ]
- Burke FM, Di Poto A, Speziale P, Foster TJ: The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site. FEBS J. 2011 Jul;278(13):2359-71. doi: 10.1111/j.1742-4658.2011.08159.x. Epub 2011 May 31. [PubMed:21569203 ]
- McCourt J, O'Halloran DP, McCarthy H, O'Gara JP, Geoghegan JA: Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistant Staphylococcus aureus strain LAC. FEMS Microbiol Lett. 2014 Apr;353(2):157-64. doi: 10.1111/1574-6968.12424. Epub 2014 Apr 10. [PubMed:24628034 ]
- Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P: Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus. J Biol Chem. 2016 Aug 26;291(35):18148-62. doi: 10.1074/jbc.M116.731125. Epub 2016 Jul 7. [PubMed:27387503 ]
- Pietrocola G, Nobile G, Alfeo MJ, Foster TJ, Geoghegan JA, De Filippis V, Speziale P: Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones. J Biol Chem. 2019 Mar 8;294(10):3588-3602. doi: 10.1074/jbc.RA118.005707. Epub 2019 Jan 8. [PubMed:30622139 ]
|
