Identification |
HMDB Protein ID
| HMDBP13395 |
Secondary Accession Numbers
| None |
Name
| Extracellular cysteine protease |
Synonyms
|
- Staphopain
|
Gene Name
| ECPA |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Cysteine protease able to cleave elastin, insulin, myoglobin, fibronectin, fibrinogen, HMW-kininogen, alpha-1-protease inhibitor and alpha-1-antitrypsin. Along with other extracellular proteases may contribute to the colonization and infection of human tissues. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
pathogenesis |
Cellular Component |
extracellular region |
cell wall |
Molecular Function |
cysteine-type peptidase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 174 |
Molecular Weight
| 19831.945 |
Theoretical pI
| 8.151 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P0C0P9 |
UniProtKB/Swiss-Prot Entry Name
| ECPA_STAEP |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A: Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis. Biol Chem. 2001 Nov;382(11):1575-82. doi: 10.1515/BC.2001.192. [PubMed:11767947 ]
- Oleksy A, Golonka E, Banbula A, Szmyd G, Moon J, Kubica M, Greenbaum D, Bogyo M, Foster TJ, Travis J, Potempa J: Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis. Biol Chem. 2004 Jun;385(6):525-35. doi: 10.1515/BC.2004.062. [PubMed:15255185 ]
|