Hmdb loader
Identification
HMDB Protein ID HMDBP13397
Secondary Accession Numbers None
Name Lysyl oxidase homolog 3
Synonyms
  1. Lysyl oxidase-like protein 3
  2. Lysyl oxidase-related protein 2
Gene Name LOXL3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:26954549). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:26307084). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (PubMed:26954549). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues on STAT3 (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
palate development
inflammatory response
peptidyl-lysine oxidation
fibronectin fibril organization
negative regulation of T-helper 17 cell lineage commitment
epithelial to mesenchymal transition
positive regulation of integrin-mediated signaling pathway
somite development
spinal cord development
negative regulation of transcription, DNA-dependent
collagen fibril organization
lung development
Cellular Component
cytoplasm
nucleus
extracellular region
extracellular space
membrane
Molecular Function
scavenger receptor activity
fibronectin binding
protein-lysine 6-oxidase activity
copper ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 754
Molecular Weight 83739.805
Theoretical pI 7.003
Pfam Domain Function
Signals
  • 1-26;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Z175
UniProtKB/Swiss-Prot Entry Name LOXL3_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Jang W, Hua A, Spilson SV, Miller W, Roe BA, Meisler MH: Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13. Genome Res. 1999 Jan;9(1):53-61. [PubMed:9927484 ]
  4. Zhang J, Yang R, Liu Z, Hou C, Zong W, Zhang A, Sun X, Gao J: Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. Hum Mol Genet. 2015 Nov 1;24(21):6174-85. doi: 10.1093/hmg/ddv333. Epub 2015 Aug 24. [PubMed:26307084 ]
  5. Kraft-Sheleg O, Zaffryar-Eilot S, Genin O, Yaseen W, Soueid-Baumgarten S, Kessler O, Smolkin T, Akiri G, Neufeld G, Cinnamon Y, Hasson P: Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016 Mar 7;36(5):550-61. doi: 10.1016/j.devcel.2016.02.009. [PubMed:26954549 ]
  6. Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE: Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell. 2017 Jan 19;65(2):296-309. doi: 10.1016/j.molcel.2016.12.002. Epub 2017 Jan 5. [PubMed:28065600 ]
  7. Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, Sun X, Gao J: Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016 Sep 20;6:33856. doi: 10.1038/srep33856. [PubMed:27645581 ]