Identification |
HMDB Protein ID
| HMDBP13400 |
Secondary Accession Numbers
| None |
Name
| Subtilisin-like serine protease Pen ch 13 |
Synonyms
|
- Alkaline serine protease
|
Gene Name
| Not Available |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Serine protease (PubMed:11893850, PubMed:16436150). Hydrolyzes casein, gelatin and human collagen type IV, but not elastin in vitro (PubMed:16436150). Hydrolyzes OCLN of the human lung epithelial cells at 202-Gln-|-Ser-203 and Gln-211-|-Ile-212 (PubMed:16436150). |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
proteolysis |
Cellular Component |
extracellular space |
Molecular Function |
IgE binding |
serine-type endopeptidase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 40361.335 |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P9WEW3 |
UniProtKB/Swiss-Prot Entry Name
| PCH13_PENRB |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Chou H, Lai HY, Tam MF, Chou MY, Wang SR, Han SH, Shen HD: cDNA cloning, biological and immunological characterization of the alkaline serine protease major allergen from Penicillium chrysogenum. Int Arch Allergy Immunol. 2002 Jan;127(1):15-26. doi: 10.1159/000048165. [PubMed:11893850 ]
- Shen HD, Lin WL, Tam MF, Wang SR, Tzean SS, Huang MH, Han SH: Characterization of allergens from Penicillium oxalicum and P. notatum by immunoblotting and N-terminal amino acid sequence analysis. Clin Exp Allergy. 1999 May;29(5):642-51. doi: 10.1046/j.1365-2222.1999.00509.x. [PubMed:10231324 ]
- Chou H, Chang CY, Tsai JJ, Tang RB, Lee SS, Wang SR, Peng HJ, Shen HD: The prevalence of IgE antibody reactivity against the alkaline serine protease major allergen of Penicillium chrysogenum increases with the age of asthmatic patients. Ann Allergy Asthma Immunol. 2003 Feb;90(2):248-53. doi: 10.1016/S1081-1206(10)62150-3. [PubMed:12602675 ]
- Tai HY, Tam MF, Chou H, Peng HJ, Su SN, Perng DW, Shen HD: Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy. 2006 Mar;61(3):382-8. doi: 10.1111/j.1398-9995.2005.00958.x. [PubMed:16436150 ]
|