| Identification |
|---|
| HMDB Protein ID
| HMDBP13413 |
| Secondary Accession Numbers
| None |
| Name
| Ent-kaurene synthase TSP4, chloroplastic |
| Synonyms
|
- Terpene synthase 4
- VacTPS4
|
| Gene Name
| TPS4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the biosynthesis of labdane-type diterpenoid including cleroda-dienols, and peregrinol lactones and furan derivatives, dopaminergic diterpenoids that can bind to dopamine receptors in the human pituitary gland, have probably ability to lower prolactin levels, and are used to treat menstrual cycle disorders (e.g. premenstrual syndrome and mastodynia) (Probable). Terpene synthase that produces ent-kaurene from ent-copalyl diphosphate (PubMed:29315936). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| gibberellin biosynthetic process |
| Cellular Component |
| chloroplast membrane |
| integral to membrane |
| Molecular Function |
| magnesium ion binding |
| ent-kaurene synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 90213.61 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A2K9RFY0 |
| UniProtKB/Swiss-Prot Entry Name
| TPS4_VITAC |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Heskes AM, Sundram TCM, Boughton BA, Jensen NB, Hansen NL, Crocoll C, Cozzi F, Rasmussen S, Hamberger B, Hamberger B, Staerk D, Moller BL, Pateraki I: Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. Plant J. 2018 Mar;93(5):943-958. doi: 10.1111/tpj.13822. Epub 2018 Feb 14. [PubMed:29315936 ]
- Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D: Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine. 2003 May;10(4):348-57. doi: 10.1078/094471103322004866. [PubMed:12809367 ]
- Liu Y, Jing SX, Luo SH, Li SH: Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis. Nat Prod Rep. 2019 Apr 17;36(4):626-665. doi: 10.1039/c8np00077h. [PubMed:30468448 ]
|
