Hmdb loader
Identification
HMDB Protein ID HMDBP13433
Secondary Accession Numbers None
Name Inactive rhomboid protein 1
Synonyms
  1. iRhom1
  2. Epidermal growth factor receptor-related protein
  3. Rhomboid 5 homolog 1
  4. Rhomboid family member 1
  5. p100hRho
Gene Name RHBDF1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of proteasomal protein catabolic process
regulation of epidermal growth factor receptor signaling pathway
protein transport
cell migration
cell proliferation
negative regulation of protein secretion
regulation of protein secretion
proteolysis
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Golgi membrane
Molecular Function
growth factor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 855
Molecular Weight 97399.87
Theoretical pI 8.444
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 412-432;656-676;692-712;715-735;747-767;773-793;804-824;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96CC6
UniProtKB/Swiss-Prot Entry Name RHDF1_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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