| Identification |
|---|
| HMDB Protein ID
| HMDBP13439 |
| Secondary Accession Numbers
| None |
| Name
| Cysteine-S-conjugate beta-lyase |
| Synonyms
|
- C-S lyase
- Cystathionine beta-lyase
- CBL
|
| Gene Name
| METC |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the cleavage of the cysteine-S bond in various cysteine-S-conjugates (PubMed:17191898, PubMed:18515361). Cleaves L-cystathionine, as well as S-substituted cysteine conjugates S-benzyl-L-cysteine and S-ethyl-L-cysteine (PubMed:17191898). Releases four human body odoriferous sulfanylalkanols: 3-methyl-3-sulfanylhexan-1-ol (3M3SH), 3-sulfanylhexan-1-ol, 2-methyl-3-sulfanylbutan-1-ol and 3-sulfanylpentan-1-ol; the release is obtained after the sequential hydrolysis of the Cys-Gly bond of the odorless Cys-Gly-S-conjugate precursors by the dipeptidase TpdA, then the cleavage of the resulting Cys-S-conjugates by MetC (PubMed:17191898, PubMed:18515361). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| biosynthetic process |
| Molecular Function |
| cystathionine beta-lyase activity |
| pyridoxal phosphate binding |
| transaminase activity |
| cysteine-S-conjugate beta-lyase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 41719.01 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q64HC5 |
| UniProtKB/Swiss-Prot Entry Name
| CBL_CORST |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Natsch A, Schmid J, Flachsmann F: Identification of odoriferous sulfanylalkanols in human axilla secretions and their formation through cleavage of cysteine precursors by a C-S lyase isolated from axilla bacteria. Chem Biodivers. 2004 Jul;1(7):1058-72. doi: 10.1002/cbdv.200490079. [PubMed:17191898 ]
- Emter R, Natsch A: The sequential action of a dipeptidase and a beta-lyase is required for the release of the human body odorant 3-methyl-3-sulfanylhexan-1-ol from a secreted Cys-Gly-(S) conjugate by Corynebacteria. J Biol Chem. 2008 Jul 25;283(30):20645-52. doi: 10.1074/jbc.M800730200. Epub 2008 May 30. [PubMed:18515361 ]
|
