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Identification
HMDB Protein ID HMDBP13479
Secondary Accession Numbers None
Name Collagen alpha-1(XVIII) chain
Synonyms Not Available
Gene Name COL18A1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).
Pathways
  • Protein digestion and absorption
Reactions Not Available
GO Classification
Biological Process
organ morphogenesis
extracellular matrix organization
cell adhesion
response to drug
angiogenesis
endothelial cell morphogenesis
visual perception
collagen fibril organization
negative regulation of cell proliferation
response to hydrostatic pressure
Cellular Component
extracellular vesicular exosome
endoplasmic reticulum lumen
basement membrane
extracellular region
collagen
collagen-containing extracellular matrix
extracellular space
extracellular matrix
Molecular Function
metal ion binding
extracellular matrix structural constituent
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1754
Molecular Weight 178186.435
Theoretical pI 6.012
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P39060
UniProtKB/Swiss-Prot Entry Name COIA1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Saarela J, Ylikarppa R, Rehn M, Purmonen S, Pihlajaniemi T: Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts. Matrix Biol. 1998 Jan;16(6):319-28. [PubMed:9503365 ]
  5. Elamaa H, Snellman A, Rehn M, Autio-Harmainen H, Pihlajaniemi T: Characterization of the human type XVIII collagen gene and proteolytic processing and tissue location of the variant containing a frizzled motif. Matrix Biol. 2003 Sep;22(5):427-42. [PubMed:14614989 ]
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  9. Sertie AL, Sossi V, Camargo AA, Zatz M, Brahe C, Passos-Bueno MR: Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome). Hum Mol Genet. 2000 Aug 12;9(13):2051-8. [PubMed:10942434 ]
  10. Iughetti P, Suzuki O, Godoi PH, Alves VA, Sertie AL, Zorick T, Soares F, Camargo A, Moreira ES, di Loreto C, Moreira-Filho CA, Simpson A, Oliva G, Passos-Bueno MR: A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma. Cancer Res. 2001 Oct 15;61(20):7375-8. [PubMed:11606364 ]
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  12. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569 ]
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