Hmdb loader
Identification
HMDB Protein ID HMDBP13484
Secondary Accession Numbers None
Name Protein GPR107
Synonyms
  1. Lung seven transmembrane receptor 1
Gene Name GPR107
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
clathrin-dependent endocytosis
Cellular Component
plasma membrane
Golgi apparatus
early endosome
nucleoplasm
clathrin-coated vesicle
membrane
integral to membrane
Molecular Function
clathrin heavy chain binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 600
Molecular Weight 66989.725
Theoretical pI 7.238
Pfam Domain Function
Signals
  • 1-39;
Transmembrane Regions
  • 264-284;294-314;338-358;369-389;403-423;499-519;525-544;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5VW38
UniProtKB/Swiss-Prot Entry Name GP107_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  7. Yosten GL, Redlinger LJ, Samson WK: Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. Am J Physiol Regul Integr Comp Physiol. 2012 Nov 1;303(9):R941-9. doi: 10.1152/ajpregu.00336.2012. Epub 2012 Aug 29. [PubMed:22933024 ]
  8. Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL: GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. J Biol Chem. 2014 Aug 29;289(35):24005-18. doi: 10.1074/jbc.M114.589275. Epub 2014 Jul 16. [PubMed:25031321 ]