Hmdb loader
Identification
HMDB Protein ID HMDBP13488
Secondary Accession Numbers None
Name Pro-FMRFamide-related neuropeptide FF
Synonyms
  1. FMRFamide-related peptides
Gene Name NPFF
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
negative regulation of appetite
negative regulation of heart rate
regulation of membrane depolarization
somatostatin secretion
vasopressin secretion
elevation of cytosolic calcium ion concentration
positive regulation of blood pressure
regulation of excitatory postsynaptic membrane potential
G-protein coupled receptor signaling pathway
acute inflammatory response to antigenic stimulus
response to drug
neuropeptide signaling pathway
spinal cord development
negative regulation of insulin secretion
regulation of sensory perception of pain
maternal process involved in female pregnancy
response to morphine
synaptic transmission
Cellular Component
dendrite
perikaryon
axon terminus
vesicle
extracellular region
postsynapse
extracellular space
Molecular Function
G protein-coupled receptor binding
receptor binding
neuropeptide hormone activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 113
Molecular Weight 12439.76
Theoretical pI 5.132
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O15130
UniProtKB/Swiss-Prot Entry Name NPFF_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Catarsi S, Babinski K, Seguela P: Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF. Neuropharmacology. 2001 Oct;41(5):592-600. [PubMed:11587714 ]
  4. Perry SJ, Yi-Kung Huang E, Cronk D, Bagust J, Sharma R, Walker RJ, Wilson S, Burke JF: A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Lett. 1997 Jun 16;409(3):426-30. doi: 10.1016/s0014-5793(97)00557-7. [PubMed:9224703 ]