| Identification |
|---|
| HMDB Protein ID
| HMDBP13489 |
| Secondary Accession Numbers
| None |
| Name
| Prothrombin |
| Synonyms
|
- Coagulation factor II
|
| Gene Name
| F2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). |
| Pathways
|
- Complement and coagulation cascades
- Coronavirus disease - COVID-19
- Neuroactive ligand-receptor interaction
- Phospholipase D signaling pathway
- Platelet activation
- Regulation of actin cytoskeleton
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of blood coagulation |
| platelet activation |
| protein polymerization |
| acute-phase response |
| proteolysis |
| Cellular Component |
| collagen-containing extracellular matrix |
| extracellular space |
| Molecular Function |
| fibrinogen binding |
| calcium ion binding |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 625 |
| Molecular Weight
| 70504.89 |
| Theoretical pI
| 6.331 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P00735 |
| UniProtKB/Swiss-Prot Entry Name
| THRB_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Irwin DM, Robertson KA, MacGillivray RT: Structure and evolution of the bovine prothrombin gene. J Mol Biol. 1988 Mar 5;200(1):31-45. doi: 10.1016/0022-2836(88)90331-2. [PubMed:3379642 ]
- MacGillivray RT, Davie EW: Characterization of bovine prothrombin mRNA and its translation product. Biochemistry. 1984 Apr 10;23(8):1626-34. doi: 10.1021/bi00303a007. [PubMed:6326805 ]
- Irwin DM, Ahern KG, Pearson GD, MacGillivray RT: Characterization of the bovine prothrombin gene. Biochemistry. 1985 Nov 19;24(24):6854-61. doi: 10.1021/bi00345a018. [PubMed:3000440 ]
- Seshadri TP, Tulinsky A, Skrzypczak-Jankun E, Park CH: Structure of bovine prothrombin fragment 1 refined at 2.25 A resolution. J Mol Biol. 1991 Jul 20;220(2):481-94. doi: 10.1016/0022-2836(91)90025-2. [PubMed:1856869 ]
- Soriano-Garcia M, Padmanabhan K, de Vos AM, Tulinsky A: The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1. Biochemistry. 1992 Mar 10;31(9):2554-66. doi: 10.1021/bi00124a016. [PubMed:1547238 ]
- Martin PD, Robertson W, Turk D, Huber R, Bode W, Edwards BF: The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution. J Biol Chem. 1992 Apr 15;267(11):7911-20. [PubMed:1560020 ]
- Vitali J, Martin PD, Malkowski MG, Robertson WD, Lazar JB, Winant RC, Johnson PH, Edwards BF: The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution. J Biol Chem. 1992 Sep 5;267(25):17670-8. [PubMed:1517214 ]
- Brandstetter H, Turk D, Hoeffken HW, Grosse D, Sturzebecher J, Martin PD, Edwards BF, Bode W: Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J Mol Biol. 1992 Aug 20;226(4):1085-99. doi: 10.1016/0022-2836(92)91054-s. [PubMed:1518046 ]
- Fuentes-Prior P, Noeske-Jungblut C, Donner P, Schleuning WD, Huber R, Bode W: Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11845-50. doi: 10.1073/pnas.94.22.11845. [PubMed:9342325 ]
- Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC: Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol. 2003 Sep;10(9):751-6. doi: 10.1038/nsb971. Epub 2003 Aug 17. [PubMed:12923575 ]
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