| Identification |
|---|
| HMDB Protein ID
| HMDBP13494 |
| Secondary Accession Numbers
| None |
| Name
| Snake venom metalloproteinase leucurolysin-A |
| Synonyms
|
- Leuc-A
- SVMP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen, as well as fibrin, fibronectin and casein. Beta and gamma chains are also hydrolyzed, but more slowly. Thrombolytic activity is also observed. Induces detachment of endothelial cells followed by death, and inhibits endothelial cell adhesion to fibronectin. Induces edema in mouse paw. Inhibits ADP-induced platelet aggregation on human platelet-rich plasma with an IC(50) of 2.8 uM. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| fibrinolysis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| metalloendopeptidase activity |
| zinc ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 23019.135 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P84907 |
| UniProtKB/Swiss-Prot Entry Name
| VM1LA_BOTLC |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Ferreira RN, Rates B, Richardson M, Guimaraes BG, Sanchez EO, Pimenta AM, Nagem RA: Complete amino-acid sequence, crystallization and preliminary X-ray diffraction studies of leucurolysin-a, a nonhaemorrhagic metalloproteinase from Bothrops leucurus snake venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):798-801. doi: 10.1107/S1744309109025767. Epub 2009 Jul 25. [PubMed:19652343 ]
- Bello CA, Hermogenes AL, Magalhaes A, Veiga SS, Gremski LH, Richardson M, Sanchez EF: Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed jararaca) snake venom. Biochimie. 2006 Feb;88(2):189-200. doi: 10.1016/j.biochi.2005.07.008. Epub 2005 Aug 19. [PubMed:16139412 ]
- Gremski LH, Chaim OM, Paludo KS, Sade YB, Otuki MF, Richardson M, Gremski W, Sanchez EF, Veiga SS: Cytotoxic, thrombolytic and edematogenic activities of leucurolysin-a, a metalloproteinase from Bothrops leucurus snake venom. Toxicon. 2007 Jul;50(1):120-34. doi: 10.1016/j.toxicon.2007.03.002. Epub 2007 Mar 14. [PubMed:17482228 ]
|
